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Legon, Wynn

Wynn Legon

Primary Appointment


Contact Information

409 Lane Rd, Rm 1031
Charlottesville, VA 22901

Research Interests

Non-invasive neuromodulation

Research Description

We study the use of ultrasound for non-invasive neuromodulation. The work in the lab employs several techniques including transcranial magnetic stimulation (TMS), electroencephalography (EEG), electromyography (EMG), magnetic resonance imaging (MRI), stereotaxic neuronavigation, computational acoustic modelling and empirical acoustic testing.

Selected Publications

Legon W, Ai L, Bansal P, Mueller JK, Neuromodulation with single-element transcranial focused ultrasound in human thalamus., 2018; Human brain mapping. () PMID: 29380485 |

Mueller JK, Ai L, Bansal P, Legon W, Numerical evaluation of the skull for human neuromodulation with transcranial focused ultrasound., 2017; Journal of neural engineering. 14(6) 066012 PMID: 28777075 |

Mueller JK, Ai L, Bansal P, Legon W, Computational exploration of wave propagation and heating from transcranial focused ultrasound for neuromodulation., 2016; Journal of neural engineering. 13(5) 056002 PMID: 27464603 |

Neren D, Johnson MD, Legon W, Bachour SP, Ling G, Divani AA, Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury., 2015; Neurocritical care. 24(2) 308-19 PMID: 26399249 |

Opitz A, Legon W, Mueller J, Barbour A, Paulus W, Tyler WJ, Is sham cTBS real cTBS? The effect on EEG dynamics., 2015; Frontiers in human neuroscience. 8() 1043 PMID: 25620925 | PMCID: PMC4287020

Legon W, Punzell S, Dowlati E, Adams SE, Stiles AB, Moran RJ, Altered Prefrontal Excitation/Inhibition Balance and Prefrontal Output: Markers of Aging in Human Memory Networks., 2015; Cerebral cortex (New York, N.Y. : 1991). 26(11) 4315-4326 PMID: 26400915 |

Mueller J, Legon W, Opitz A, Sato TF, Tyler WJ, Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics., 2014; Brain stimulation. 7(6) 900-8 PMID: 25265863 |

Legon W, Sato TF, Opitz A, Mueller J, Barbour A, Williams A, Tyler WJ, Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans., 2014; Nature neuroscience. 17(2) 322-9 PMID: 24413698 |

Legon W, Dionne JK, Staines WR, Continuous theta burst stimulation of the supplementary motor area: effect upon perception and somatosensory and motor evoked potentials., 2013; Brain stimulation. 6(6) 877-83 PMID: 23706289 |

Opitz A, Legon W, Rowlands A, Bickel WK, Paulus W, Tyler WJ, Physiological observations validate finite element models for estimating subject-specific electric field distributions induced by transcranial magnetic stimulation of the human motor cortex., 2013; NeuroImage. 81() 253-64 PMID: 23644000 |

Dionne JK, Legon W, Staines WR, Crossmodal influences on early somatosensory processing: interaction of vision, touch, and task-relevance., 2013; Experimental brain research. 226(4) 503-12 PMID: 23455852 |

Legon W, Rowlands A, Opitz A, Sato TF, Tyler WJ, Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and FMRI., 2012; PloS one. 7(12) e51177 PMID: 23226567 | PMCID: PMC3514181

Neva JL, Legon W, Staines WR, Primary motor cortex excitability is modulated with bimanual training., 2012; Neuroscience letters. 514(2) 147-51 PMID: 22405809 |

Legon W, Dionne JK, Meehan SK, Staines WR, Non-dominant hand movement facilitates the frontal N30 somatosensory evoked potential., 2010; BMC neuroscience. 11() 112 PMID: 20822535 | PMCID: PMC2940928

Dionne JK, Meehan SK, Legon W, Staines WR, Crossmodal influences in somatosensory cortex: Interaction of vision and touch., 2009; Human brain mapping. 31(1) 14-25 PMID: 19572308 |

Meehan SK, Legon W, Staines WR, Spatiotemporal properties modulate intermodal influences on early somatosensory processing during sensory-guided movement., 2009; Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 120(7) 1371-80 PMID: 19501547 |

Meehan SK, Legon W, Staines WR, Paired-pulse transcranial magnetic stimulation of primary somatosensory cortex differentially modulates perception and sensorimotor transformations., 2008; Neuroscience. 157(2) 424-31 PMID: 18838111 |

Legon W, Meehan SK, Staines WR, The relationship between frontal somatosensory-evoked potentials and motor planning., 2008; Neuroreport. 19(1) 87-91 PMID: 18281899 |

Legon W, Staines WR, Predictability of the target stimulus for sensory-guided movement modulates early somatosensory cortical potentials., 2006; Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 117(6) 1345-53 PMID: 16644272 |