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Eyo, Ukpong

Ukpong Eyo

Primary Appointment


Contact Information

6144 MR-4 Building
Charlottesville, VA 22908

Research Interests


Research Description

Microglia in neurodevelopment and neurodevelopment disorders

Selected Publications

Uweru JO, Eyo UB, A decade of diverse microglial-neuronal physical interactions in the brain (2008-2018)., 2019; Neuroscience letters. 698() 33-38 PMID: 30625349 | PMCID: PMC6435396

Zhou LJ, Peng J, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Lin ZJ, Liu Y, Murugan M, Eyo UB, Umpierre AD, Xin WJ, Chen T, Li M, Wang H, Richardson JR, Tan Z, Liu XG, Wu LJ, Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain., 2019; Cell reports. 27(13) 3844-3859.e6 PMID: 31242418 |

Mo M, Eyo UB, Xie M, Peng J, Bosco DB, Umpierre AD, Zhu X, Tian DS, Xu P, Wu LJ, Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections., 2019; The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(47) 9453-9464 PMID: 31597724 | PMCID: PMC6867812

Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, Wu LJ, Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling., 2019; Nature neuroscience. 22(11) 1771-1781 PMID: 31636449 | PMCID: PMC6858573

Eyo UB, Wu LJ, Microglia: Lifelong patrolling immune cells of the brain., 2019; Progress in neurobiology. 179() 101614 PMID: 31075285 | PMCID: PMC6599472

Bosco DB, Zheng J, Xu Z, Peng J, Eyo UB, Tang K, Yan C, Huang J, Feng L, Wu G, Richardson JR, Wang H, Wu LJ, RNAseq analysis of hippocampal microglia after kainic acid-induced seizures., 2018; Molecular brain. 11(1) 34 PMID: 29925434 | PMCID: PMC6011524

Eyo UB, Mo M, Yi MH, Murugan M, Liu J, Yarlagadda R, Margolis DJ, Xu P, Wu LJ, P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape., 2018; Cell reports. 23(4) 959-966 PMID: 29694903 | PMCID: PMC5965271

Eyo UB, Bispo A, Liu J, Sabu S, Wu R, DiBona VL, Zheng J, Murugan M, Zhang H, Tang Y, Wu LJ, The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions., 2018; Scientific reports. 8(1) 828 PMID: 29339791 | PMCID: PMC5770428

Zhao X, Eyo UB, Murugan M, Wu LJ, Microglial interactions with the neurovascular system in physiology and pathology., 2018; Developmental neurobiology. 78(6) 604-617 PMID: 29318762 | PMCID: PMC5980686

Eyo UB, Peng J, Murugan M, Mo M, Lalani A, Xie P, Xu P, Margolis DJ, Wu LJ, Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus., 2017; eNeuro. 3(6) PMID: 28101527 | PMCID: PMC5237828

Tian DS, Peng J, Murugan M, Feng LJ, Liu JL, Eyo UB, Zhou LJ, Mogilevsky R, Wang W, Wu LJ, Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1? Production after Status Epilepticus., 2017; The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(33) 7878-7892 PMID: 28716963 | PMCID: PMC5559763

Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ, Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury., 2016; Cell reports. 16(3) 605-14 PMID: 27373153 | PMCID: PMC4956495

Eyo UB, Murugan M, Wu LJ, Microglia-Neuron Communication in Epilepsy., 2016; Glia. 65(1) 5-18 PMID: 27189853 | PMCID: PMC5116010

Swiatkowski P, Murugan M, Eyo UB, Wang Y, Rangaraju S, Oh SB, Wu LJ, Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury., 2016; Neuroscience. 318() 22-33 PMID: 26791526 | PMCID: PMC4753827

Gu N, Eyo UB, Murugan M, Peng J, Matta S, Dong H, Wu LJ, Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain., 2015; Brain, behavior, and immunity. 55() 82-92 PMID: 26576724 | PMCID: PMC4864135

Eyo UB, Miner SA, Weiner JA, Dailey ME, Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus., 2015; Brain, behavior, and immunity. 55() 49-59 PMID: 26576723 | PMCID: PMC4864211

Liu J, Tian D, Murugan M, Eyo UB, Dreyfus CF, Wang W, Wu LJ, Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage., 2015; Journal of neurochemistry. 135(2) 347-56 PMID: 26173779 | PMCID: PMC4721248

Eyo UB, Gu N, De S, Dong H, Richardson JR, Wu LJ, Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium., 2015; The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(6) 2417-22 PMID: 25673836 | PMCID: PMC4323526

Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ, Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus., 2014; The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(32) 10528-40 PMID: 25100587 | PMCID: PMC4200107

Dailey ME, Eyo U, Fuller L, Hass J, Kurpius D, Imaging microglia in brain slices and slice cultures., 2013; Cold Spring Harbor protocols. 2013(12) 1142-8 PMID: 24298036 |

Eyo UB, Wu LJ, Bidirectional microglia-neuron communication in the healthy brain., 2013; Neural plasticity. 2013() 456857 PMID: 24078884 | PMCID: PMC3775394

Eyo UB, Miner SA, Ahlers KE, Wu LJ, Dailey ME, P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation., 2013; Neuropharmacology. 73() 311-9 PMID: 23770338 | PMCID: PMC3786777

Eyo UB, Dailey ME, Microglia: key elements in neural development, plasticity, and pathology., 2013; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 8(3) 494-509 PMID: 23354784 | PMCID: PMC3657325

Eyo U, Dailey ME, Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues., 2012; Glia. 60(11) 1747-60 PMID: 22847985 | PMCID: PMC3786781