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Larson, Tracy

Tracy Larson

Primary Appointment


Contact Information

PO Box 400328
Telephone: (434) 297-7946

Research Interests

Integrative Behavioral Neuroscience

Research Description

Tracy Larson explores the origins, functions, and mechanisms underlying natural variation in the spatial and temporal patterns of adult neurogenesis by integrating behavioral genomics, comparative neuroanatomy, and cellular biology with mechanistic studies. Larson?s current studies utilize the unique relationship between plasticity in birth and death of neurons in the songbird brain and the ability of the songbird to sing high quality, ?attractive? song. Questions she explores include: What are the mechanisms that promote regeneration of the adult brain? Can mechanisms that are robust in songbirds be exploited to encourage the addition of new functional neurons in the poorly regenerating mammalian brain? What cellular mechanisms modulate adult neurogenesis and how have they evolved?

Selected Publications

Lewis VM, Saunders LM, Larson TA, Bain EJ, Sturiale SL, Gur D, Chowdhury S, Flynn JD, Allen MC, Deheyn DD, Lee JC, Simon JA, Lippincott-Schwartz J, Raible DW, Parichy DM, Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores., 2019; Proceedings of the National Academy of Sciences of the United States of America. 116(24) 11806-11811 PMID: 31138706 | PMCID: PMC6575160

Larson TA, Sex Steroids, Adult Neurogenesis, and Inflammation in CNS Homeostasis, Degeneration, and Repair., 2018; Frontiers in endocrinology. 9() 205 PMID: 29760681 | PMCID: PMC5936772

Larson TA, Thatra NM, Hou D, Hu RA, Brenowitz EA, Seasonal changes in neuronal turnover in a forebrain nucleus in adult songbirds., 2018; The Journal of comparative neurology. 527(4) 767-779 PMID: 30291632 | PMCID: PMC6333494

Ben-Hamo M, Larson TA, Duge LS, Sikkema C, Wilkinson CW, de la Iglesia HO, Gonz?lez MM, Circadian Forced Desynchrony of the Master Clock Leads to Phenotypic Manifestation of Depression in Rats., 2017; eNeuro. 3(6) PMID: 28090585 | PMCID: PMC5216685

Larson TA, Lent KL, Bammler TK, MacDonald JW, Wood WE, Caras ML, Thatra NM, Budzillo A, Perkel DJ, Brenowitz EA, Network analysis of microRNA and mRNA seasonal dynamics in a highly plastic sensorimotor neural circuit., 2015; BMC genomics. 16() 905 PMID: 26545368 | PMCID: PMC4636775

Brenowitz EA, Larson TA, Neurogenesis in the adult avian song-control system., 2015; Cold Spring Harbor perspectives in biology. 7(6) PMID: 26032719 | PMCID: PMC4448602

Larson TA, Thatra NM, Lee BH, Brenowitz EA, Reactive neurogenesis in response to naturally occurring apoptosis in an adult brain., 2014; The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(39) 13066-76 PMID: 25253853 | PMCID: PMC4172801

Larson TA, Wang TW, Gale SD, Miller KE, Thatra NM, Caras ML, Perkel DJ, Brenowitz EA, Postsynaptic neural activity regulates neuronal addition in the adult avian song control system., 2013; Proceedings of the National Academy of Sciences of the United States of America. 110(41) 16640-4 PMID: 24062453 | PMCID: PMC3799304

Larson TA, Gordon TN, Lau HE, Parichy DM, Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation., 2010; Developmental biology. 346(2) 296-309 PMID: 20692250 | PMCID: PMC2957186