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Redemann, Stefanie

Stefanie Redemann

Primary Appointment

Molecular Physiology and Biological Physics

Contact Information

480 Ray C. Hunt Drive
Charlottesville, Va 22903
Telephone: 4342431413

Research Interests

Chromosome segregation and aneuploidy in meiosis and mitosis

Research Description

Mitotic spindles are highly dynamic, microtubule based constructions that function to segregate the chromosomes during cell division. The dynamic properties of microtubules in spindles are modulated by many factors, including polymerases, depolymerases, motor proteins, cross-linkers and other microtubule associated proteins, of which many are conserved throughout eukaryotic organisms. Despite this evolutionary conservation of essential factors, there is a remarkable variability in spindle organization and mechanics between organisms and tissues within species. The Redemann Lab is interested in uncovering and understanding the underlying principles of spindle assembly on a nano-scale level. We are using a combination of large scale 3D reconstruction of spindles by electron tomography and state-of-the-art light microscopy to investigate the mechanisms and principles of spindle assembly and chromosome segregation. Ultimately we are using the dynamic and ultra structural data to develop and test models of spindle formation and mechanics. List of Publications in Pubmed

Selected Publications

Redemann S, Baumgart J, Lindow N, Shelley M, Nazockdast E, Kratz A, Prohaska S, Brugu?s J, F?rthauer S, M?ller-Reichert T, C. elegans chromosomes connect to centrosomes by anchoring into the spindle network., 2017; Nature communications. 8() 15288 PMID: 28492281 | PMCID: PMC5437269

P?cr?aux J, Redemann S, Alayan Z, Mercat B, Pastezeur S, Garzon-Coral C, Hyman AA, Howard J, The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability., 2016; Biophysical journal. 111(8) 1773-1784 PMID: 27760363 | PMCID: PMC5071606

Redemann S, Weber B, M?ller M, Verbavatz JM, Hyman AA, Baum D, Prohaska S, M?ller-Reichert T, The segmentation of microtubules in electron tomograms using Amira., 2014; Methods in molecular biology (Clifton, N.J.). 1136() 261-78 PMID: 24633801 |

Redemann S, M?ller-Reichert T, Correlative light and electron microscopy for the analysis of cell division., 2013; Journal of microscopy. 251(2) 109-12 PMID: 23734865 |

Redemann S, Schloissnig S, Ernst S, Pozniakowsky A, Ayloo S, Hyman AA, Bringmann H, Codon adaptation-based control of protein expression in C. elegans., 2011; Nature methods. 8(3) 250-2 PMID: 21278743 |

Redemann S, Pecreaux J, Goehring NW, Khairy K, Stelzer EH, Hyman AA, Howard J, Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos., 2010; PloS one. 5(8) e12301 PMID: 20808841 | PMCID: PMC2924899

Newby Lambert M, V?cker E, Blumberg S, Redemann S, Gajraj A, Meiners JC, Walter NG, Mg2+-induced compaction of single RNA molecules monitored by tethered particle microscopy., 2006; Biophysical journal. 90(10) 3672-85 PMID: 16500956 | PMCID: PMC1440748

Mendoza M, Redemann S, Brunner D, The fission yeast MO25 protein functions in polar growth and cell separation., 2005; European journal of cell biology. 84(12) 915-26 PMID: 16325501 |