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Onengut-Gumuscu, Suna

Suna Onengut-Gumuscu

Primary Appointment

Medicine- Endocrinology and Metabolism

Contact Information

Telephone: 2-0366

Research Interests

Genetics of Type 1 Diabetes

Research Description

My research focuses on understanding the genetic causes of complex diseases. The lab is particularly interested in identification of genetic variants that influence the development of Type 1 diabetes (T1D). T1D is a complex disorder, which arises from the autoimmune destruction of the insulin secreting b-cells of the pancreas leading to a life-long dependence on exogenous insulin. The increased concordance rates for T1D in monozygotic, as opposed to dizygotic twins as well as the tendency for the disorder to cluster within families suggest that a portion of the risk for T1D is inherited. We use a variety of genomic tools, high throughput oriented technology and analysis methods to reveal the molecular mechanisms underlying genetic risk in Type 1 Diabetes. Ultimately identification of the genetic risk factors that play a role in type 1 diabetes will help us understand the mechanisms that lead to autoimmunity in T1D and assist researchers in devising preventive and therapeutic treatments.

Selected Publications

Han B, Pouget JG, Slowikowski K, Stahl E, Lee CH, Diogo D, Hu X, Park YR, Kim E, Gregersen PK, Dahlqvist SR, Worthington J, Martin J, Eyre S, Klareskog L, Huizinga T, Chen WM, Onengut-Gumuscu S, Rich SS, Wray NR, Raychaudhuri S, A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases., 2016; Nature genetics. 48(7) 803-10 PMID: 27182969 | PMCID: PMC4925284

Ge Y, Onengut-Gumuscu S, Quinlan AR, Mackey AJ, Wright JA, Buckner JH, Habib T, Rich SS, Concannon P, Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes., 2015; Diabetes. 65(3) 794-802 PMID: 26631741 | PMCID: PMC4764149

Hu X, Deutsch AJ, Lenz TL, Onengut-Gumuscu S, Han B, Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, Raychaudhuri S, Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk., 2015; Nature genetics. 47(8) 898-905 PMID: 26168013 | PMCID: PMC4930791

Wallace C, Cutler AJ, Pontikos N, Pekalski ML, Burren OS, Cooper JD, Garc?a AR, Ferreira RC, Guo H, Walker NM, Smyth DJ, Rich SS, Onengut-Gumuscu S, Sawcer SJ, Ban M, Richardson S, Todd JA, Wicker LS, Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping., 2015; PLoS genetics. 11(6) e1005272 PMID: 26106896 | PMCID: PMC4481316

Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E, Bonnie JK, Szpak M, Schofield E, Achuthan P, Guo H, Fortune MD, Stevens H, Walker NM, Ward LD, Kundaje A, Kellis M, Daly MJ, Barrett JC, Cooper JD, Deloukas P, ..., Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers., 2015; Nature genetics. 47(4) 381-6 PMID: 25751624 | PMCID: PMC4380767

Zanda M, Onengut-Gumuscu S, Walker N, Shtir C, Gallo D, Wallace C, Smyth D, Todd JA, Hurles ME, Plagnol V, Rich SS, A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes., 2014; PLoS genetics. 10(5) e1004367 PMID: 24875393 | PMCID: PMC4038470

Tomlinson MJ, Pitsillides A, Pickin R, Mika M, Keene K, Hou X, Mychaleckyj J, Chen WM, Concannon P, Onengut-Gumuscu S, Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13., 2014; Diabetes. () PMID: 25008175 | PMCID: PMC4237999

Jia X, Han B, Onengut-Gumuscu S, Chen WM, Concannon PJ, Rich SS, Raychaudhuri S, de Bakker PI, Imputing amino acid polymorphisms in human leukocyte antigens., 2013; PloS one. 8(6) e64683 PMID: 23762245 | PMCID: PMC3675122