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Onengut-Gumuscu, Suna

Suna Onengut-Gumuscu

Primary Appointment

Medicine- Endocrinology and Metabolism

Contact Information

Telephone: 2-0366

Research Interests

Genetics of Type 1 Diabetes

Research Description

My research focuses on understanding the genetic causes of complex diseases. The lab is particularly interested in identification of genetic variants that influence the development of type 1 diabetes (T1D). T1D is a complex disorder, which arises from the autoimmune destruction of the insulin secreting b-cells of the pancreas leading to a life-long dependence on exogenous insulin. The increased concordance rates for T1D in monozygotic, as opposed to dizygotic twins as well as the tendency for the disorder to cluster within families suggest that a portion of the risk for T1D is inherited. We use a variety of genomic tools, high throughput oriented technology and analysis methods to reveal the molecular mechanisms underlying genetic risk in T1D. Ultimately identification of the genetic risk factors that play a role in T1D will help us understand the mechanisms that lead to autoimmunity in T1D and assist researchers in devising preventive and therapeutic treatments.

Selected Publications

Fern?ndez-Casta?eda A, Chappell MS, Rosen DA, Seki SM, Beiter RM, Johanson DM, Liskey D, Farber E, Onengut-Gumuscu S, Overall CC, Dupree JL, Gaultier A, The active contribution of OPCs to neuroinflammation is mediated by LRP1., 2019; Acta neuropathologica. () PMID: 31552482 |

Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C, Cao JJ, Valo E, Onengut-Gumuscu S, Smiles AM, McGurnaghan SJ, Haukka JK, Harjutsalo V, Brennan EP, van Zuydam N, Ahlqvist E..., Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen., 2019; Journal of the American Society of Nephrology : JASN. 30(10) 2000-2016 PMID: 31537649 | PMCID: PMC6779358

Onengut-Gumuscu S, Chen WM, Robertson CC, Bonnie JK, Farber E, Zhu Z, Oksenberg JR, Brant SR, Bridges SL, Edberg JC, Kimberly RP, Gregersen PK, Rewers MJ, Steck AK, Black MH, Dabelea D, Pihoker C, Atkinson MA, Wagenknecht LE, Divers J, Bell RA, Er..., Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score., 2019; Diabetes care. 42(3) 406-415 PMID: 30659077 | PMCID: PMC6385701

Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark ?, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG, Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families., 2019; Diabetes. 68(4) 847-857 PMID: 30655385 | PMCID: PMC6425872

Singh S, Wang L, Schaff DL, Sutcliffe MD, Koeppel AF, Kim J, Onengut-Gumuscu S, Park KS, Zong H, Janes KA, In situ 10-cell RNA sequencing in tissue and tumor biopsy samples., 2019; Scientific reports. 9(1) 4836 PMID: 30894605 | PMCID: PMC6426952

M?rquez A, Kerick M, Zhernakova A, Gutierrez-Achury J, Chen WM, Onengut-Gumuscu S, Gonz?lez-?lvaro I, Rodriguez-Rodriguez L, Rios-Fern?ndez R, Gonz?lez-Gay MA, Mayes MD, Raychaudhuri S, Rich SS, Wijmenga C, Mart?n J, Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations., 2018; Genome medicine. 10(1) 97 PMID: 30572963 | PMCID: PMC6302306

Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J, Publisher Correction: Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease., 2018; Nature. 564(7734) E7 PMID: 30397347 |

Westra HJ, Mart?nez-Bonet M, Onengut-Gumuscu S, Lee A, Luo Y, Teslovich N, Worthington J, Martin J, Huizinga T, Klareskog L, Rantapaa-Dahlqvist S, Chen WM, Quinlan A, Todd JA, Eyre S, Nigrovic PA, Gregersen PK, Rich SS, Raychaudhuri S, Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes., 2018; Nature genetics. 50(10) 1366-1374 PMID: 30224649 | PMCID: PMC6364548

Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J, Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease., 2018; Nature. 560(7717) 185-191 PMID: 30046111 | PMCID: PMC6085146

Sharma A, Liu X, Hadley D, Hagopian W, Chen WM, Onengut-Gumuscu S, T?rn C, Steck AK, Frohnert BI, Rewers M, Ziegler AG, Lernmark ?, Toppari J, Krischer JP, Akolkar B, Rich SS, She JX, Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort., 2018; Journal of autoimmunity. 89() 90-100 PMID: 29310926 | PMCID: PMC5902429

Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS, Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release., 2018; Nature. 563(7733) 714-718 PMID: 30464343 | PMCID: PMC6331005

Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS, Context-dependent compensation among phosphatidylserine-recognition receptors., 2017; Scientific reports. 7(1) 14623 PMID: 29116131 | PMCID: PMC5676788

Shi Y, Stornetta RL, Stornetta DS, Onengut-Gumuscu S, Farber EA, Turner SD, Guyenet PG, Bayliss DA, Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus., 2017; The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(48) 11744-11757 PMID: 29066557 | PMCID: PMC5707768

Norris JM, Lee HS, Frederiksen B, Erlund I, Uusitalo U, Yang J, Lernmark ?, Simell O, Toppari J, Rewers M, Ziegler AG, She JX, Onengut-Gumuscu S, Chen WM, Rich SS, Sundvall J, Akolkar B, Krischer J, Virtanen SM, Hagopian W, Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity., 2017; Diabetes. 67(1) 146-154 PMID: 29061729 | PMCID: PMC5741144

Newman JRB, Conesa A, Mika M, New FN, Onengut-Gumuscu S, Atkinson MA, Rich SS, McIntyre LM, Concannon P, Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes., 2017; Genome research. 27(11) 1807-1815 PMID: 29025893 | PMCID: PMC5668939

Manichaikul A, Wang XQ, Sun L, Dupuis J, Borczuk AC, Nguyen JN, Raghu G, Hoffman EA, Onengut-Gumuscu S, Farber EA, Kaufman JD, Rabinowitz D, Stukovsky KDH, Kawut SM, Hunninghake GM, Washko GR, O'Connor GT, Rich SS, Barr RG, Lederer DJ, Genome-wide association study of subclinical interstitial lung disease in MESA., 2017; Respiratory research. 18(1) 97 PMID: 28521775 | PMCID: PMC5437638

Marin IA, Goertz JE, Ren T, Rich SS, Onengut-Gumuscu S, Farber E, Wu M, Overall CC, Kipnis J, Gaultier A, Microbiota alteration is associated with the development of stress-induced despair behavior., 2017; Scientific reports. 7() 43859 PMID: 28266612 | PMCID: PMC5339726

Steck AK, Xu P, Geyer S, Redondo MJ, Antinozzi P, Wentworth JM, Sosenko J, Onengut-Gumuscu S, Chen WM, Rich SS, Pugliese A, Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?, 2017; The Journal of clinical endocrinology and metabolism. 102(8) 2873-2880 PMID: 28520980 | PMCID: PMC5546868

Manichaikul A, Sun L, Borczuk AC, Onengut-Gumuscu S, Farber EA, Mathai SK, Zhang W, Raghu G, Kaufman JD, Hinckley-Stukovsky KD, Kawut SM, Jelic S, Liu W, Fingerlin TE, Schwartz DA, Sell JL, Rich SS, Barr RG, Lederer DJ, Plasma Soluble Receptor for Advanced Glycation End Products in Idiopathic Pulmonary Fibrosis., 2017; Annals of the American Thoracic Society. 14(5) 628-635 PMID: 28248552 | PMCID: PMC5427736

Han B, Pouget JG, Slowikowski K, Stahl E, Lee CH, Diogo D, Hu X, Park YR, Kim E, Gregersen PK, Dahlqvist SR, Worthington J, Martin J, Eyre S, Klareskog L, Huizinga T, Chen WM, Onengut-Gumuscu S, Rich SS, Wray NR, Raychaudhuri S, A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases., 2016; Nature genetics. 48(7) 803-10 PMID: 27182969 | PMCID: PMC4925284

Han CZ, Juncadella IJ, Kinchen JM, Buckley MW, Klibanov AL, Dryden K, Onengut-Gumuscu S, Erdbr?gger U, Turner SD, Shim YM, Tung KS, Ravichandran KS, Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation., 2016; Nature. 539(7630) 570-574 PMID: 27820945 | PMCID: PMC5799085

Ge Y, Onengut-Gumuscu S, Quinlan AR, Mackey AJ, Wright JA, Buckner JH, Habib T, Rich SS, Concannon P, Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes., 2015; Diabetes. 65(3) 794-802 PMID: 26631741 | PMCID: PMC4764149

Hu X, Deutsch AJ, Lenz TL, Onengut-Gumuscu S, Han B, Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, Raychaudhuri S, Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk., 2015; Nature genetics. 47(8) 898-905 PMID: 26168013 | PMCID: PMC4930791

Wallace C, Cutler AJ, Pontikos N, Pekalski ML, Burren OS, Cooper JD, Garc?a AR, Ferreira RC, Guo H, Walker NM, Smyth DJ, Rich SS, Onengut-Gumuscu S, Sawcer SJ, Ban M, Richardson S, Todd JA, Wicker LS, Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping., 2015; PLoS genetics. 11(6) e1005272 PMID: 26106896 | PMCID: PMC4481316

Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E, Bonnie JK, Szpak M, Schofield E, Achuthan P, Guo H, Fortune MD, Stevens H, Walker NM, Ward LD, Kundaje A, Kellis M, Daly MJ, Barrett JC, Cooper JD, Deloukas P, ..., Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers., 2015; Nature genetics. 47(4) 381-6 PMID: 25751624 | PMCID: PMC4380767

Zanda M, Onengut-Gumuscu S, Walker N, Shtir C, Gallo D, Wallace C, Smyth D, Todd JA, Hurles ME, Plagnol V, Rich SS, A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes., 2014; PLoS genetics. 10(5) e1004367 PMID: 24875393 | PMCID: PMC4038470

Tomlinson MJ, Pitsillides A, Pickin R, Mika M, Keene K, Hou X, Mychaleckyj J, Chen WM, Concannon P, Onengut-Gumuscu S, Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13., 2014; Diabetes. () PMID: 25008175 | PMCID: PMC4237999

Jia X, Han B, Onengut-Gumuscu S, Chen WM, Concannon PJ, Rich SS, Raychaudhuri S, de Bakker PI, Imputing amino acid polymorphisms in human leukocyte antigens., 2013; PloS one. 8(6) e64683 PMID: 23762245 | PMCID: PMC3675122