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Pathophysiology and Treatment of Type 2 Diabetes
A primary mission of the Applied Metabolism & Physiology (AMP) Laboratory is ?Metabolic Performance?. To that extent, a chief metabolic focus of our laboratory is to understand the pathophysiology of type 2 diabetes and identify novel strategies in which exercise minimizes insulin resistance for the prevention and treatment of type-2 diabetes across the lifespan. While exercise and low-fat diets combat obesity and reduce risk for chronic diseases, the optimal prescription remains unclear. Further complicating this matter is the fact that not all children and adults respond the same way to exercise, pharmacology, or bariatric surgery. Therefore, determining how to personalize exercise and diet modification for maximal metabolic fitness benefit in individuals at risk for chronic disease, and understanding the mechanisms behind such changes provides an ideal approach to promoting long-term metabolic health. We are currently working on: 1. Tailoring exercise prescription to prevent the progression from prediabetes to type 2 diabetes in children and adults. 2. Examining how to incorporate physical activity and dietary modification to enhance the efficacy and durability of bariatric surgery on appetite and glucose regulation. 3. Determining how lifestyle modification and bariatric surgery interacts with pharmacology to regulate body weight and cardiometabolic health. 4. Gain mechanistic understanding into energy metabolism and endocrine-related inflammation by which lifestyle modification and bariatric surgery improves metabolic fitness.