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Malin, Steven

Steven Malin

Primary Appointment

Kinesiology

Contact Information

Telephone: 434-243-6624
Fax: 434-924-1389
Email: skm6n@virginia.edu

Research Interests

Pathophysiology and Treatment of Type 2 Diabetes

Research Description

A primary mission of the Applied Metabolism & Physiology (AMP) Laboratory is ?Metabolic Performance?. To that extent, a chief metabolic focus of our laboratory is to understand the pathophysiology of type 2 diabetes and identify novel strategies in which exercise minimizes insulin resistance for the prevention and treatment of type-2 diabetes across the lifespan. While exercise and low-fat diets combat obesity and reduce risk for chronic diseases, the optimal prescription remains unclear. Further complicating this matter is the fact that not all children and adults respond the same way to exercise, pharmacology, or bariatric surgery. Therefore, determining how to personalize exercise and diet modification for maximal metabolic fitness benefit in individuals at risk for chronic disease, and understanding the mechanisms behind such changes provides an ideal approach to promoting long-term metabolic health. We are currently working on: 1. Tailoring exercise prescription to prevent the progression from prediabetes to type 2 diabetes in children and adults. 2. Examining how to incorporate physical activity and dietary modification to enhance the efficacy and durability of bariatric surgery on appetite and glucose regulation. 3. Determining how lifestyle modification and bariatric surgery interacts with pharmacology to regulate body weight and cardiometabolic health. 4. Gain mechanistic understanding into energy metabolism and endocrine-related inflammation by which lifestyle modification and bariatric surgery improves metabolic fitness.

Selected Publications

Malin SK, Kashyap SR, Effects of various gastrointestinal procedures on ?-cell function in obesity and type 2 diabetes., 2016; Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 12(6) 1213-9 PMID: 27568472 |

Malin SK, Kashyap SR, Type 2 Diabetes Treatment in the Patient with Obesity., 2016; Endocrinology and metabolism clinics of North America. 45(3) 553-64 PMID: 27519130 |

Malin SK, Rynders CA, Weltman JY, Jackson Roberts L, Barrett EJ, Weltman A, Endothelial function following glucose ingestion in adults with prediabetes: Role of exercise intensity., 2016; Obesity (Silver Spring, Md.). 24(7) 1515-21 PMID: 27221649 | PMCID: PMC4925188

Mehaffey JH, Mullen MG, Mehaffey RL, Turrentine FE, Malin SK, Kirby JL, Schirmer B, Hallowell PT, Type 2 diabetes remission following gastric bypass: does diarem stand the test of time?, 2016; Surgical endoscopy. () PMID: 27177952 |

Malin SK, Rynders CA, Weltman JY, Barrett EJ, Weltman A, Exercise Intensity Modulates Glucose-Stimulated Insulin Secretion when Adjusted for Adipose, Liver and Skeletal Muscle Insulin Resistance., 2016; PloS one. 11(4) e0154063 PMID: 27111219 | PMCID: PMC4844153

Malin SK, Liu Z, Barrett EJ, Weltman A, Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism., 2016; Reviews in endocrine & metabolic disorders. 17(1) 81-90 PMID: 27106830 |

Malin SK, Kashyap SR, Differences in Weight Loss and Gut Hormones: Rouen-Y Gastric Bypass and Sleeve Gastrectomy Surgery., 2015; Current obesity reports. 4(2) 279-86 PMID: 26627222 |

Malin SK, Braun B, Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower Type 2 Diabetes Risk., 2015; Exercise and sport sciences reviews. 44(1) 4-11 PMID: 26583801 |

Rynders CA, Weltman JY, Malin SK, Jiang B, Breton M, Barrett EJ, Weltman A, Comparing Simple Insulin Sensitivity Indices to the Oral Minimal Model Postexercise., 2015; Medicine and science in sports and exercise. () PMID: 26154337 |