Mobile Menu Button

Abbott, Stephen

Stephen Abbott

Primary Appointment


Contact Information

1340 Jefferson Park Ave.
Charlottesville, VA 22908
Telephone: 434- 924-5849
Fax: 434-982-3878

Research Interests

Neurobiology of the autonomic nervous system and the homeostatic control of breathing

Research Description

Neurobiology of cardiovascular and respiratory homeostasis

Selected Publications

Guyenet PG, Stornetta RL, Holloway BB, Souza GMP, Abbott SBG, Rostral Ventrolateral Medulla and Hypertension., 2018; Hypertension (Dallas, Tex. : 1979). 72(3) 559-566 PMID: 30354763 | PMCID: PMC6324579

Machado NLS, Abbott SBG, Resch JM, Zhu L, Arrigoni E, Lowell BB, Fuller PM, Fontes MAP, Saper CB, A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia., 2018; Current biology : CB. 28(14) 2291-2301.e5 PMID: 30017482 | PMCID: PMC6085892

Abbott SBG, Saper CB, Role of the median preoptic nucleus in the autonomic response to heat-exposure., 2018; Temperature (Austin, Tex.). 5(1) 4-6 PMID: 29687039 | PMCID: PMC5902207

Souza GMP, Kanbar R, Stornetta DS, Abbott SBG, Stornetta RL, Guyenet PG, Breathing regulation and blood gas homeostasis after near complete lesions of the retrotrapezoid nucleus in adult rats., 2018; The Journal of physiology. 596(13) 2521-2545 PMID: 29667182 | PMCID: PMC6023841

Kim SJ, Fong AY, Pilowsky PM, Abbott SBG, Sympathoexcitation following intermittent hypoxia in rat is mediated by circulating angiotensin II acting at the carotid body and subfornical organ., 2018; The Journal of physiology. 596(15) 3217-3232 PMID: 29645283 | PMCID: PMC6068222

Guyenet PG, Bayliss DA, Stornetta RL, Kanbar R, Shi Y, Holloway BB, Souza GMP, Basting TM, Abbott SBG, Wenker IC, Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus., 2017; The Journal of physiology. 596(15) 3029-3042 PMID: 29168167 | PMCID: PMC6068251

Pedersen NP, Ferrari L, Venner A, Wang JL, Abbott SBG, Vujovic N, Arrigoni E, Saper CB, Fuller PM, Supramammillary glutamate neurons are a key node of the arousal system., 2017; Nature communications. 8(1) 1405 PMID: 29123082 | PMCID: PMC5680228

Abbott SBG, Saper CB, Median preoptic glutamatergic neurons promote thermoregulatory heat loss and water consumption in mice., 2017; The Journal of physiology. 595(20) 6569-6583 PMID: 28786483 | PMCID: PMC5638873

Abbott SB, Machado NL, Geerling JC, Saper CB, Reciprocal Control of Drinking Behavior by Median Preoptic Neurons in Mice., 2016; The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(31) 8228-37 PMID: 27488641 | PMCID: PMC4971367

Geerling JC, Kim M, Mahoney CE, Abbott SB, Agostinelli LJ, Garfield AS, Krashes MJ, Lowell BB, Scammell TE, Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus., 2015; American journal of physiology. Regulatory, integrative and comparative physiology. 310(1) R41-54 PMID: 26491097 | PMCID: PMC4747895

Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SB, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA, PHYSIOLOGY. Regulation of breathing by CO? requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons., 2015; Science (New York, N.Y.). 348(6240) 1255-60 PMID: 26068853 | PMCID: PMC5171229

Abbott SB, DePuy SD, Nguyen T, Coates MB, Stornetta RL, Guyenet PG, Selective optogenetic activation of rostral ventrolateral medullary catecholaminergic neurons produces cardiorespiratory stimulation in conscious mice., 2013; The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(7) 3164-77 PMID: 23407970 | PMCID: PMC3596815

Abbott SB, Coates MB, Stornetta RL, Guyenet PG, Optogenetic stimulation of c1 and retrotrapezoid nucleus neurons causes sleep state-dependent cardiorespiratory stimulation and arousal in rats., 2013; Hypertension (Dallas, Tex. : 1979). 61(4) 835-41 PMID: 23438930 | PMCID: PMC3666866

Guyenet PG, Abbott SB, Chemoreception and asphyxia-induced arousal., 2013; Respiratory physiology & neurobiology. 188(3) 333-43 PMID: 23608705 | PMCID: PMC3749262

Derecki NC, Cronk JC, Lu Z, Xu E, Abbott SB, Guyenet PG, Kipnis J, Wild-type microglia arrest pathology in a mouse model of Rett syndrome., 2012; Nature. 484(7392) 105-9 PMID: 22425995 | PMCID: PMC3321067

Abbott SB, Kanbar R, Bochorishvili G, Coates MB, Stornetta RL, Guyenet PG, C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats., 2012; The Journal of physiology. 590(0) 2897-915 PMID: 22526887 | PMCID: PMC3448155

Guyenet PG, Stornetta RL, Abbott SB, Depuy SD, Kanbar R, The retrotrapezoid nucleus and breathing., 2012; Advances in experimental medicine and biology. 758() 115-22 PMID: 23080151 | PMCID: PMC5111164

Abbott SB, Stornetta RL, Coates MB, Guyenet PG, Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats., 2011; The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(45) 16410-22 PMID: 22072691 | PMCID: PMC3236529

Abbott SB, Stornetta RL, Fortuna MG, Depuy SD, West GH, Harris TE, Guyenet PG, Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats., 2009; The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(18) 5806-19 PMID: 19420248 | PMCID: PMC2696034