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Stornetta, Ruth

Ruth Stornetta

Primary Appointment

Pharmacology

Contact Information

PO Box 800735
Charlottesville, VA 22908
Telephone: 434-982-3977
Fax: 434-982-3878
Email: rs3j@virginia.edu

Research Interests

Role of endogenous peptides in control of cardiorespiratory function

Research Description

My research interests have centered on understanding the biochemical, pharmacological, physiological and anatomical basis of the role of neuropeptides, endogenous opiates, GABA and glycine in the control of cardiorespiratory function. My current research is to understand how the C1 adrenergic neurons of the lower brainstem might control the autonomic responses to physiological stressors, how these neurons might be heterogeneous and trying to determine markers associated with specific functions. The current projects involve microscopic analysis of rodent brains after procedures to reveal specific mRNAs or proteins expressed by these neurons.

Selected Publications

Bochorishvili G, Nguyen T, Coates MB, Viar KE, Stornetta RL, Guyenet PG, The orexinergic neurons receive synaptic input from C1 cells in rats., 2014; The Journal of comparative neurology. 522(17) 3834-46 PMID: 24984694 | PMCID: PMC4167913

Guyenet PG, Abbott SB, Stornetta RL, The respiratory chemoreception conundrum: light at the end of the tunnel?, 2012; Brain research. 1511() 126-37 PMID: 23088963 | PMCID: PMC3570739

Guyenet PG, Stornetta RL, Abbott SB, Depuy SD, Fortuna MG, Kanbar R, Central CO2 chemoreception and integrated neural mechanisms of cardiovascular and respiratory control., 2010; Journal of applied physiology (Bethesda, Md. : 1985). 108(4) 995-1002 PMID: 20075262 | PMCID: PMC2853202

Kanbar R, Stornetta RL, Cash DR, Lewis SJ, Guyenet PG, Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats., 2010; American journal of respiratory and critical care medicine. 182(9) 1184-94 PMID: 20622037 | PMCID: PMC3001261

Stornetta RL, Neurochemistry of bulbospinal presympathetic neurons of the medulla oblongata., 2009; Journal of chemical neuroanatomy. 38(3) 222-30 PMID: 19665549 | PMCID: PMC2760958

Takakura AC, Moreira TS, Stornetta RL, West GH, Gwilt JM, Guyenet PG, Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats., 2008; The Journal of physiology. 586(0) 2975-91 PMID: 18440993 | PMCID: PMC2517201

Stornetta RL, Identification of neurotransmitters and co-localization of transmitters in brainstem respiratory neurons., 2008; Respiratory physiology & neurobiology. 164(1) 18-27 PMID: 18722563 | PMCID: PMC2642910