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Abounader, Roger

Roger Abounader

Primary Appointment

Microbiology, Immunology, and Cancer Biology

Contact Information

OMS-4 Bldg., Rm 4819
Charlottesville, VA 22908
Telephone: 434-982-6634
Email: ra6u@virginia.edu
Website: https://www.abounaderlab.org/

Research Interests

Basic and translational brain tumor research

Research Description

Our research focuses on understanding the molecular basis of brain tumor development and growth and on using the acquired knowledge to identify new targets and develop new approaches for experimental brain tumor therapy. Specifically, the following projects are ongoing in my lab at this time: Project 1: To study the role of non-coding RNAs in brain tumor malignancy and uncover new therapeutic targets Non-coding RNAs are regulatory RNAs that play important roles in regulating normal and cancer biology. We are studying the expressions, targets, mechanisms of action and functions of microRNAs, TUCRs and lncRNAs in gliomas. The goal is to understand their role in brain tumor development and growth and identify new therapeutic targets in brain tumors. Project 2: To study the roles and therapeutic targeting of MET and other RTKs in brain tumors. We have previously established the MET pathway as a contributor to brain tumor malignancy and growth. Clinically applicable inhibitors of MET have been subsequently developed but have thus far failed to achieve significant effects in human patients. We hypothesized that this failure is due to signaling redundancy and compensatory mechanisms involving various other pathways and molecules including other RTKs. Our goals are to understand how MET interacts with these pathways and molecules at the molecular and functional levels, and to use this understanding to develop new therapies that target MET in combination with other molecules in order to achieve greater anti-tumor effects. We are also interested in uncovering the determinants of sensitivity and resistance to MET inhibitors in order to better select patients that will benefit for MET inhibition and to develop new approaches for overcoming resistance to anti-MET drugs. We are also exploring conceptually novel approaches that are based on our new discoveries on ligand-induced oncogene addiction and microRNAs to enhance the efficacy of anti-RTK therapies. Project 3: To investigate Transcribed Ultra-Conserved Regions (TUCR) and long non-coding RNAs (lncRNA) in gliomas TUCR are regions of the genome that are greater than 200 base pairs in length and are highly conserved across two or more species, showing 100% conservation in human, mouse, and rat genomes. A subset of TUCRs are lncRNAs. The expression of TUCRs is commonly deregulated in cancer, where they might exert crucial regulatory roles as lncRNAs. However, the literature elucidating their functional roles and their mechanisms of action in cancer is very sparse, with the literature on their role in glioblastoma being inexistent. This project aims to identify TUCRs that are differentially expressed in glioblastoma, uncover potential correlations with clinical parameters, determine their functional role and mechanisms of action, and evaluate their potential as therapeutic targets. Project 4: To assess the roles and therapeutic targeting of T-Type calcium channels in glioblastoma We are performing a comprehensive investigation of the roles and potential therapeutic exploitation of T-type calcium channels in glioblastoma. Project 5: To investigate the role and therapeutic targeting of TERT promoter mutant glioblastoma We are investigating role and effects of targeting the transcription factor GABP as a new indirect approach to targeting TERT mutant glioblastoma.

Selected Publications

Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, Park DM, Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma., 2019; Cancer research. 79(20) 5218-5232 PMID: 31488423 | PMCID: PMC6801103

Yang Y, Dodbele S, Park T, Glass R, Bhat K, Sulman EP, Zhang Y, Abounader R, MicroRNA-29a inhibits glioblastoma stem cells and tumor growth by regulating the PDGF pathway., 2019; Journal of neuro-oncology. 145(1) 23-34 PMID: 31482267 |

Ngulde SI, Sandabe UK, Abounader R, Dawson TK, Zhang Y, Iliya I, Hussaini IM, Ethanol Extract of Securidaca longipedunculata Induces Apoptosis in Brain Tumor (U87) Cells., 2019; BioMed research international. 2019() 9826590 PMID: 30931334 | PMCID: PMC6413385

Melhuish TA, Kowalczyk I, Manukyan A, Zhang Y, Shah A, Abounader R, Wotton D, Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression., 2018; Biochimica et biophysica acta. Gene regulatory mechanisms. 1861(11) 983-995 PMID: 30312684 | PMCID: PMC6203443

Cruickshanks N, Zhang Y, Hine S, Gibert M, Yuan F, Oxford M, Grello C, Pahuski M, Dube C, Guessous F, Wang B, Deveau C, Saoud K, Gallagher I, Wulfkuhle J, Schiff D, Phan S, Petricoin E, Abounader R, Discovery and Therapeutic Exploitation of Mechanisms of Resistance to MET Inhibitors in Glioblastoma., 2018; Clinical cancer research : an official journal of the American Association for Cancer Research. 25(2) 663-673 PMID: 30201763 | PMCID: PMC6335175

Zhang Y, Dube C, Gibert M, Cruickshanks N, Wang B, Coughlan M, Yang Y, Setiady I, Deveau C, Saoud K, Grello C, Oxford M, Yuan F, Abounader R, The p53 Pathway in Glioblastoma., 2018; Cancers. 10(9) PMID: 30200436 | PMCID: PMC6162501

Zhang Y, Kim J, Mueller AC, Dey B, Yang Y, Lee DH, Hachmann J, Finderle S, Park DM, Christensen J, Schiff D, Purow B, Dutta A, Abounader R, Correction to: Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma., 2018; Cell death and differentiation. 26(1) 197 PMID: 29899381 | PMCID: PMC6294759

Gonzalez PP, Kim J, Galvao RP, Cruickshanks N, Abounader R, Zong H, p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression., 2018; Glia. 66(5) 999-1015 PMID: 29392777 |

Olmez I, Zhang Y, Manigat L, Benamar M, Brenneman B, Nakano I, Godlewski J, Bronisz A, Lee J, Abbas T, Abounader R, Purow B, Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma., 2018; Cancer research. 78(15) 4360-4369 PMID: 29844123 | PMCID: PMC6072607

Abounader R, A new practical and versatile mouse model of proneural glioblastoma., 2018; Neuro-oncology. 20(3) 299-301 PMID: 29432618 | PMCID: PMC5817963

Olmez I, Love S, Xiao A, Manigat L, Randolph P, McKenna BD, Neal BP, Boroda S, Li M, Brenneman B, Abounader R, Floyd D, Lee J, Nakano I, Godlewski J, Bronisz A, Sulman EP, Mayo M, Gioeli D, Weber M, Harris TE, Purow B, Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha., 2017; Neuro-oncology. () PMID: 29048560 | PMCID: PMC5777487

Olmez I, Brenneman B, Xiao A, Serbulea V, Benamar M, Zhang Y, Manigat L, Abbas T, Lee J, Nakano I, Godlewski J, Bronisz A, Abounader R, Leitinger N, Purow B, Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms., 2017; Clinical cancer research : an official journal of the American Association for Cancer Research. 23(22) 6958-6968 PMID: 28814434 | PMCID: PMC5690820

Cruickshanks N, Zhang Y, Yuan F, Pahuski M, Gibert M, Abounader R, Role and Therapeutic Targeting of the HGF/MET Pathway in Glioblastoma., 2017; Cancers. 9(7) PMID: 28696366 | PMCID: PMC5532623

Zhang Y, Cruickshanks N, Yuan F, Wang B, Pahuski M, Wulfkuhle J, Gallagher I, Koeppel AF, Hatef S, Papanicolas C, Lee J, Bar EE, Schiff D, Turner SD, Petricoin EF, Gray LS, Abounader R, Targetable T-type Calcium Channels Drive Glioblastoma., 2017; Cancer research. 77(13) 3479-3490 PMID: 28512247 | PMCID: PMC5505315

Reon BJ, Anaya J, Zhang Y, Mandell J, Purow B, Abounader R, Dutta A, Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis., 2016; PLoS medicine. 13(12) e1002192 PMID: 27923049 | PMCID: PMC5140055

Vega RA, Zhang Y, Curley C, Price RL, Abounader R, 370?Magnetic Resonance-Guided Focused Ultrasound Delivery of Polymeric Brain-Penetrating Nanoparticle MicroRNA Conjugates in Glioblastoma., 2016; Neurosurgery. 63() 210 PMID: 27399567 |

Lee DH, Zhang Y, Kassam AB, Park MJ, Gardner P, Prevedello D, Henry S, Horbinski C, Beumer JH, Tawbi H, Williams BJ, Shaffrey ME, Egorin MJ, Abounader R, Park DM, Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma., 2015; PloS one. 10(8) e0134426 PMID: 26247786 | PMCID: PMC4527706

Negishi M, Wongpalee SP, Sarkar S, Park J, Lee KY, Shibata Y, Reon BJ, Abounader R, Suzuki Y, Sugano S, Dutta A, A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins., 2014; PloS one. 9(4) e95216 PMID: 24748121 | PMCID: PMC3991591

Feng C, Zhang Y, Yin J, Li J, Abounader R, Zuo Z, Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma., 2014; Neuro-oncology. 16(8) 1078-85 PMID: 24526308 | PMCID: PMC4096175

Floyd DH, Zhang Y, Dey BK, Kefas B, Breit H, Marks K, Dutta A, Herold-Mende C, Synowitz M, Glass R, Abounader R, Purow BW, Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim., 2014; PloS one. 9(5) e96239 PMID: 24805821 | PMCID: PMC4013090

Zhang Y, Schiff D, Park D, Abounader R, MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET., 2014; PloS one. 9(3) e91546 PMID: 24621885 | PMCID: PMC3951453

Awad AJ, Burns TC, Zhang Y, Abounader R, Targeting MET for glioma therapy., 2014; Neurosurgical focus. 37(6) E10 PMID: 25434379 |

Kim J, Zhang Y, Skalski M, Hayes J, Kefas B, Schiff D, Purow B, Parsons S, Lawler SE, Abounader R, microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma., 2014; Cancer research. () PMID: 24425048 | PMCID: PMC3947487

Zhang Y, Kim J, Mueller AC, Dey B, Yang Y, Lee DH, Hachmann J, Finderle S, Park DM, Christensen J, Schiff D, Purow B, Dutta A, Abounader R, Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma., 2014; Cell death and differentiation. 21(5) 720-34 PMID: 24440911 | PMCID: PMC3978301

Kefas B, Floyd DH, Comeau L, Frisbee A, Dominguez C, Dipierro CG, Guessous F, Abounader R, Purow B, A miR-297/hypoxia/DGK-? axis regulating glioblastoma survival., 2013; Neuro-oncology. 15(12) 1652-63 PMID: 24158111 | PMCID: PMC3829588

Guessous F, Alvarado-Velez M, Marcinkiewicz L, Zhang Y, Kim J, Heister S, Kefas B, Godlewski J, Schiff D, Purow B, Abounader R, Oncogenic effects of miR-10b in glioblastoma stem cells., 2013; Journal of neuro-oncology. 112(2) 153-63 PMID: 23307328 | PMCID: PMC3609924

Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, Schiff D, Mandell J, Abounader R, A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy., 2013; Neoplasia (New York, N.Y.). 15(8) 952-65 PMID: 23908595 | PMCID: PMC3730046

Zhang Y, Farenholtz KE, Yang Y, Guessous F, Dipierro CG, Calvert VS, Deng J, Schiff D, Xin W, Lee JK, Purow B, Christensen J, Petricoin E, Abounader R, Hepatocyte growth factor sensitizes brain tumors to c-MET kinase inhibition., 2013; Clinical cancer research : an official journal of the American Association for Cancer Research. 19(6) 1433-44 PMID: 23386689 | PMCID: PMC3602223

Kofman AV, Kim J, Park SY, Dupart E, Letson C, Bao Y, Ding K, Chen Q, Schiff D, Larner J, Abounader R, microRNA-34a promotes DNA damage and mitotic catastrophe., 2013; Cell cycle (Georgetown, Tex.). 12(22) 3500-11 PMID: 24091633 | PMCID: PMC3906336

Dominguez CL, Floyd DH, Xiao A, Mullins GR, Kefas BA, Xin W, Yacur MN, Abounader R, Lee JK, Wilson GM, Harris TE, Purow BW, Diacylglycerol kinase ? is a critical signaling node and novel therapeutic target in glioblastoma and other cancers., 2013; Cancer discovery. 3(7) 782-97 PMID: 23558954 | PMCID: PMC3710531

Kofman AV, Letson C, Dupart E, Bao Y, Newcomb WW, Schiff D, Brown J, Abounader R, The p53-microRNA-34a axis regulates cellular entry receptors for tumor-associated human herpes viruses., 2013; Medical hypotheses. 81(1) 62-7 PMID: 23643704 | PMCID: PMC3676726

Zhang Y, Dutta A, Abounader R, The role of microRNAs in glioma initiation and progression., 2011; Frontiers in bioscience : a journal and virtual library. 17() 700-12 PMID: 22201769 | PMCID: PMC3278211

Kofman AV, Abounader R, When tumor cells make blood vessels: implications for glioblastoma therapy., 2011; Future oncology (London, England). 7(7) 841-3 PMID: 21732755 | PMCID: PMC3278210

Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, Kotelevskaya E, Brown J, Schiff D, Abounader R, The roles of viruses in brain tumor initiation and oncomodulation., 2011; Journal of neuro-oncology. 105(3) 451-66 PMID: 21720806 | PMCID: PMC3278219

Catania A, Maira F, Skarmoutsou E, D'Amico F, Abounader R, Mazzarino MC, Insight into the role of microRNAs in brain tumors (review)., 2011; International journal of oncology. 40(3) 605-24 PMID: 22179098 |

Guessous F, Yang Y, Johnson E, Marcinkiewicz L, Smith M, Zhang Y, Kofman A, Schiff D, Christensen J, Abounader R, Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy., 2011; Molecular cancer therapeutics. 11(2) 288-97 PMID: 22188814 | PMCID: PMC3277676

Zhang Y, Guessous F, Kofman A, Schiff D, Abounader R, XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC., 2010; IDrugs : the investigational drugs journal. 13(2) 112-21 PMID: 20127563 | PMCID: PMC3268517

Guessous F, Zhang Y, Kofman A, Catania A, Li Y, Schiff D, Purow B, Abounader R, microRNA-34a is tumor suppressive in brain tumors and glioma stem cells., 2010; Cell cycle (Georgetown, Tex.). 9(6) 1031-6 PMID: 20190569 | PMCID: PMC3278213

Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, Johnson E, Marcinkiewicz L, Jiang J, Yang Y, Schmittgen TD, Lopes B, Schiff D, Purow B, Abounader R, MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes., 2009; Cancer research. 69(19) 7569-76 PMID: 19773441 | PMCID: PMC2756313

Kefas B, Comeau L, Floyd DH, Seleverstov O, Godlewski J, Schmittgen T, Jiang J, diPierro CG, Li Y, Chiocca EA, Lee J, Fine H, Abounader R, Lawler S, Purow B, The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors., 2009; The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48) 15161-8 PMID: 19955368 | PMCID: PMC2823067

Li Y, Guessous F, DiPierro C, Zhang Y, Mudrick T, Fuller L, Johnson E, Marcinkiewicz L, Engelhardt M, Kefas B, Schiff D, Kim J, Abounader R, Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy., 2009; Molecular cancer therapeutics. 8(2) 376-85 PMID: 19190120 |

Abounader R, Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapy., 2009; Expert review of anticancer therapy. 9(2) 235-45 PMID: 19192961 | PMCID: PMC2678856

Guessous F, Zhang Y, diPierro C, Marcinkiewicz L, Sarkaria J, Schiff D, Buchanan S, Abounader R, An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth., 2009; Anti-cancer agents in medicinal chemistry. 10(1) 28-35 PMID: 20015006 | PMCID: PMC3278215

Li Y, Guessous F, Kwon S, Kumar M, Ibidapo O, Fuller L, Johnson E, Lal B, Hussaini I, Bao Y, Laterra J, Schiff D, Abounader R, PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations., 2008; Cancer research. 68(6) 1723-31 PMID: 18339852 | PMCID: PMC3813002

Guessous F, Li Y, Abounader R, Signaling pathways in medulloblastoma., 2008; Journal of cellular physiology. 217(3) 577-83 PMID: 18651559 |

Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B, microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma., 2008; Cancer research. 68(10) 3566-72 PMID: 18483236 |

Reznik TE, Sang Y, Ma Y, Abounader R, Rosen EM, Xia S, Laterra J, Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor., 2008; Molecular cancer research : MCR. 6(1) 139-50 PMID: 18234969 | PMCID: PMC2839502

Li Y, Guessous F, Johnson EB, Eberhart CG, Li XN, Shu Q, Fan S, Lal B, Laterra J, Schiff D, Abounader R, Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma., 2007; Laboratory investigation; a journal of technical methods and pathology. 88(2) 98-111 PMID: 18059365 |

Xu J, Gao M, Fan S, Meng Q, Goldberg ID, Abounader R, Ressom H, Laterra JJ, Rosen EM, Effect of Akt inhibition on scatter factor-regulated gene expression in DU-145 human prostate cancer cells., 2006; Oncogene. 26(20) 2925-38 PMID: 17099727 |

Abounader R, Laterra J, Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis., 2005; Neuro-oncology. 7(4) 436-51 PMID: 16212809 | PMCID: PMC1871724

Beckner ME, Gobbel GT, Abounader R, Burovic F, Agostino NR, Laterra J, Pollack IF, Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis., 2005; Laboratory investigation; a journal of technical methods and pathology. 85(12) 1457-70 PMID: 16170333 |

Lal B, Xia S, Abounader R, Laterra J, Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation., 2005; Clinical cancer research : an official journal of the American Association for Cancer Research. 11(12) 4479-86 PMID: 15958633 |

Li Y, Lal B, Kwon S, Fan X, Saldanha U, Reznik TE, Kuchner EB, Eberhart C, Laterra J, Abounader R, The scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor malignancy., 2005; Cancer research. 65(20) 9355-62 PMID: 16230398 |

Abounader R, Reznik T, Colantuoni C, Martinez-Murillo F, Rosen EM, Laterra J, Regulation of c-Met-dependent gene expression by PTEN., 2004; Oncogene. 23(57) 9173-82 PMID: 15516982 |

Liang H, O'Reilly S, Liu Y, Abounader R, Laterra J, Maher VM, McCormick JJ, Sp1 regulates expression of MET, and ribozyme-induced down-regulation of MET in fibrosarcoma-derived human cells reduces or eliminates their tumorigenicity., 2004; International journal of oncology. 24(5) 1057-67 PMID: 15067326 |

Abounader R, Montgomery R, Dietz H, Laterra J, Design and expression of chimeric U1/ribozyme transgenes., 2004; Methods in molecular biology (Clifton, N.J.). 252() 209-19 PMID: 15017051 |

Su W, Gutmann DH, Perry A, Abounader R, Laterra J, Sherman LS, CD44-independent hepatocyte growth factor/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro., 2004; Glia. 45(3) 297-306 PMID: 14730703 |

Jiang WG, Grimshaw D, Martin TA, Davies G, Parr C, Watkins G, Lane J, Abounader R, Laterra J, Mansel RE, Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET., 2003; Clinical cancer research : an official journal of the American Association for Cancer Research. 9(11) 4274-81 PMID: 14519655 |

Herynk MH, Stoeltzing O, Reinmuth N, Parikh NU, Abounader R, Laterra J, Radinsky R, Ellis LM, Gallick GE, Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells., 2003; Cancer research. 63(11) 2990-6 PMID: 12782608 |

Bannon DI, Abounader R, Lees PS, Bressler JP, Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells., 2002; American journal of physiology. Cell physiology. 284(1) C44-50 PMID: 12388109 |

Moreno MJ, Abounader R, H?bert E, Doods H, Hamel E, Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment., 2002; Neuropharmacology. 42(4) 568-76 PMID: 11955527 |

Abounader R, Lal B, Luddy C, Koe G, Davidson B, Rosen EM, Laterra J, In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis., 2001; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 16(1) 108-10 PMID: 11729097 |

Jiang WG, Grimshaw D, Lane J, Martin TA, Abounader R, Laterra J, Mansel RE, Abounder R, A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells., 2001; Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8) 2555-62 PMID: 11489839 |

Abounader R, Ranganathan S, Kim BY, Nichols C, Laterra J, Signaling pathways in the induction of c-met receptor expression by its ligand scatter factor/hepatocyte growth factor in human glioblastoma., 2001; Journal of neurochemistry. 76(5) 1497-508 PMID: 11238734 |

Dumont Y, Cadieux A, Doods H, Pheng LH, Abounader R, Hamel E, Jacques D, Regoli D, Quirion R, BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist., 2000; British journal of pharmacology. 129(6) 1075-88 PMID: 10725255 | PMCID: PMC1571943

Bowers DC, Fan S, Walter KA, Abounader R, Williams JA, Rosen EM, Laterra J, Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways., 2000; Cancer research. 60(15) 4277-83 PMID: 10945642 |

Guerin C, Luddy C, Abounader R, Lal B, Laterra J, Glioma inhibition by HGF/NK2, an antagonist of scatter factor/hepatocyte growth factor., 2000; Biochemical and biophysical research communications. 273(1) 287-93 PMID: 10873600 |

Abounader R, Ranganathan S, Lal B, Fielding K, Book A, Dietz H, Burger P, Laterra J, Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression., 1999; Journal of the National Cancer Institute. 91(18) 1548-56 PMID: 10491431 |

Book AA, Ranganathan S, Abounader R, Rosen E, Laterra J, Scatter factor/hepatocyte growth factor gene transfer increases rat blood-glioma barrier permeability., 1999; Brain research. 833(2) 173-80 PMID: 10375692 |

Abounader R, Elhusseiny A, Cohen Z, Olivier A, Stanimirovic D, Quirion R, Hamel E, Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture., 1999; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 19(2) 155-63 PMID: 10027771 |

Abounader R, Hamel E, Associations between neuropeptide Y nerve terminals and intraparenchymal microvessels in rat and human cerebral cortex., 1997; The Journal of comparative neurology. 388(3) 444-53 PMID: 9368852 |

Vogel J, Abounader R, Schr?ck H, Zeller K, Duelli R, Kuschinsky W, Parallel changes of blood flow and heterogeneity of capillary plasma perfusion in rat brains during hypocapnia., 1996; The American journal of physiology. 270(4) H1441-5 PMID: 8967387 |

Abounader R, Villemure JG, Hamel E, Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226., 1995; British journal of pharmacology. 116(4) 2245-50 PMID: 8564255 | PMCID: PMC1908978

Abounader R, Vogel J, Kuschinsky W, Patterns of capillary plasma perfusion in brains in conscious rats during normocapnia and hypercapnia., 1995; Circulation research. 76(1) 120-6 PMID: 8001269 |