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Adler, Paul

Paul Adler

Primary Appointment

Biology

Contact Information

Telephone: 982-5475/5476
Email: pna@virginia.edu
Website: http://www.hsc.virginia.edu/internet/cancer-research/membership/members/adler.cfm

Research Interests

Planar signaling, polarity and morphogenesis.

Research Description

My major research interest is the genetic control of morphogenesis at the interface between the cell and tissue levels. As a model system we have studied planar polarity in the Drosophila wing, which is covered with an array of distally pointing hairs. We have found hair polarity is controlled via regulating the subcellular location for initiation of the growth of the hair. This site selection is under the control of the frizzled planar cell polarity pathway. It is thought that a key step in this process involves the accumulation of protein complexes along the proximal and distal sides of wing cells. A major focus of the laboratory is to understand how these asymmetric protein complexes specify the site for activation of the actin and microtubule cytoskeletons to elaborate the hair. Homologs of the frizzled pathway genes function to control gastrulation in the vertebrate embryo, polarity of the stereocillia in the inner ear and some have been implicatedin oncogenesis. We are also studying how cells insure the integrity of cellular extensions such as hairs, bristles and dendrites. Once again we are using the Drosophila epidermis as a model. We have found that the tricornered and furry genes play a key role in this process and that these proteins accumulate in growing extensions. Our working model is that these proteins function in targeting intracellular transport to insure proper morphogenesis. Once again these genes are widely conserved and their homologs have been found to be important for cell polarity and shape in fungi, worms and flies. Related genes have been found to be involved in cancer formation in mammals and tumorous outgrowths in flies.

Selected Publications

Lu Q, Adler PN, The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis., 2015; PloS one. 10(3) e0115623 PMID: 25730111 | PMCID: PMC4346269

Fagan JK, Dollar G, Lu Q, Barnett A, Pechuan Jorge J, Schlosser A, Pfleger C, Adler P, Jenny A, Combover/CG10732, a novel PCP effector for Drosophila wing hair formation., 2014; PloS one. 9(9) e107311 PMID: 25207969 | PMCID: PMC4160248

Wang Y, Yan J, Lee H, Lu Q, Adler PN, The proteins encoded by the Drosophila Planar Polarity Effector genes inturned, fuzzy and fritz interact physically and can re-pattern the accumulation of "upstream" Planar Cell Polarity proteins., 2014; Developmental biology. 394(1) 156-69 PMID: 25072625 | PMCID: PMC4163512

Adler PN, Sobala LF, Thom D, Nagaraj R, dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing., 2013; Developmental biology. 379(1) 76-91 PMID: 23623898 | PMCID: PMC3686509

Nagaraj R, Adler PN, Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development., 2012; Development (Cambridge, England). 139(5) 906-16 PMID: 22278919 | PMCID: PMC3274354

Lu Q, Yan J, Adler PN, The Drosophila planar polarity proteins inturned and multiple wing hairs interact physically and function together., 2010; Genetics. 185(2) 549-58 PMID: 20351219 | PMCID: PMC2881136

Fang X, Adler PN, Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes., 2010; Developmental biology. 341(2) 360-74 PMID: 20211163 | PMCID: PMC2862085

Yan J, Lu Q, Fang X, Adler PN, Rho1 has multiple functions in Drosophila wing planar polarity., 2009; Developmental biology. 333(1) 186-99 PMID: 19576201 | PMCID: PMC2728161

Taylor J, Adler PN, Cell rearrangement and cell division during the tissue level morphogenesis of evaginating Drosophila imaginal discs., 2007; Developmental biology. 313(2) 739-51 PMID: 18082159 | PMCID: PMC2258245

Ren N, Charlton J, Adler PN, The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells., 2007; Genetics. 176(4) 2223-34 PMID: 17565945 | PMCID: PMC1950627

Chung S, Kim S, Yoon J, Adler PN, Yim J, The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing., 2007; Genetics. 176(2) 891-903 PMID: 17409077 | PMCID: PMC1894616