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Civelek, Mete

Mete Civelek

Primary Appointment

Biomedical Engineering

Contact Information

OMS, Room 3836A
Charlottesville, VA 22908
Telephone: 434-243-1669
Fax: 434-924-1312
Email: mc2wq@virginia.edu
Website: http://civeleklab.org/

Research Interests

Systems Genetics Approaches to Understand Cardiometabolic Traits

Research Description

The goal of our laboratory is to understand the genetic mechanisms that lead to increased susceptibility to cardiovascular and metabolic diseases. The interactions among hundreds of genes and gene networks along with environmental factors such as diet affect our health status. We use systems genetics to uncover this complexity. We use a range of experimental and computational methods to quantitate and integrate intermediate phenotypes, such as transcript, protein or metabolite levels, in human and mouse populations. We also test our predictions using standard biochemistry and molecular biology approaches in cell cultures and animal models. Our results provided insights into both the molecular underpinnings of complex traits and the understanding of common, complex diseases.

Selected Publications

Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K, Dual peroxisome-proliferator-activated-receptor-?/? activation inhibits SIRT1-PGC1? axis and causes cardiac dysfunction., 2019; JCI insight. 5() PMID: 31393858 |

Thibord F, Hardy L, Ibrahim-Kosta M, Saut N, Pulcrano-Nicolas AS, Goumidi L, Civelek M, Eriksson P, Deleuze JF, Le Goff W, Tr?gou?t DA, Morange PE, A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process., 2019; Journal of thrombosis and haemostasis : JTH. () PMID: 31271701 |

Civelek M, Erdmann J, miRNAs and regulation of cardiometabolic phenotypes - novel insights into the complexity of GWAS loci., 2019; Cardiovascular research. () PMID: 31086972 |

Sharma NK, Chuang Key CC, Civelek M, Wabitsch M, Comeau ME, Langefeld CD, Parks JS, Das SK, Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans., 2019; Diabetes. 68(7) 1508-1522 PMID: 31010960 | PMCID: PMC6609988

Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG, The E3 ligase MARCH5 is a PPAR? target gene that regulates mitochondria and metabolism in adipocytes., 2018; American journal of physiology. Endocrinology and metabolism. 316(2) E293-E304 PMID: 30512991 | PMCID: PMC6397360

Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y, Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics., 2018; Proceedings of the National Academy of Sciences of the United States of America. 115(48) E11349-E11358 PMID: 30429326 | PMCID: PMC6275533

Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhl?n M, Tr?gou?t DA, Renn? T, Odeberg J, Butler LM, A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein., 2018; Scientific reports. 8(1) 14668 PMID: 30279450 | PMCID: PMC6168570

Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, Lusis AJ, Pellegrini M, Epigenome-wide association in adipose tissue from the METSIM cohort., 2018; Human molecular genetics. 27(14) 2586 PMID: 29893869 | PMCID: PMC6030960

Pan DZ, Garske KM, Alvarez M, Bhagat YV, Boocock J, Nikkola E, Miao Z, Raulerson CK, Cantor RM, Civelek M, Glastonbury CA, Small KS, Boehnke M, Lusis AJ, Sinsheimer JS, Mohlke KL, Laakso M, Pajukanta P, Ko A, Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS., 2018; Nature communications. 9(1) 1512 PMID: 29666371 | PMCID: PMC5904163

Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, M?kinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koi..., A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism., 2018; Cell metabolism. 27(5) 1138-1155.e6 PMID: 29719227 | PMCID: PMC5935137

Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, Lusis AJ, Pellegrini M, Epigenome-wide association in adipose tissue from the METSIM cohort., 2018; Human molecular genetics. 27(10) 1830-1846 PMID: 29566149 | PMCID: PMC5932563

Small KS, Todor?evi? M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Vi?uela A, Tsai PC, Nag A, Buil A, Thorleifsson G, R..., Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition., 2018; Nature genetics. 50(4) 572-580 PMID: 29632379 | PMCID: PMC5935235

Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P, Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA., 2018; Nature medicine. 24(3) 304-312 PMID: 29431742 | PMCID: PMC5839972

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, B..., Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes., 2018; Nature genetics. 50(4) 524-537 PMID: 29531354 | PMCID: PMC5968830

Civelek M, A Smoking-Associated miRNA-mRNA Coexpression Network., 2017; Circulation. Cardiovascular genetics. 10(5) PMID: 29030404 | PMCID: PMC5679253

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL,..., The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue., 2017; Cell reports. 20(1) 279 PMID: 28683320 | PMCID: PMC6502642

Cannon ME, Duan Q, Wu Y, Zeynalzadeh M, Xu Z, Kangas AJ, Soininen P, Ala-Korpela M, Civelek M, Lusis AJ, Kuusisto J, Collins FS, Boehnke M, Tang H, Laakso M, Li Y, Mohlke KL, Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus., 2017; G3 (Bethesda, Md.). 7(9) 3217-3227 PMID: 28754724 | PMCID: PMC5592946

Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stan??kov? A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T, Collins FS, Gargalovic PS, B..., Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits., 2017; American journal of human genetics. 100(3) 428-443 PMID: 28257690 | PMCID: PMC5339333

Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM, HIF-1? is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium., 2017; eLife. 6() PMID: 28556776 | PMCID: PMC5495571

Kessler T, Wobst J, Wolf B, Eckhold J, Vilne B, Hollstein R, von Ameln S, Dang TA, Sager HB, Moritz Rumpf P, Aherrahrou R, Kastrati A, Bj?rkegren JLM, Erdmann J, Lusis AJ, Civelek M, Kaiser FJ, Schunkert H, Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus., 2017; Circulation. 136(5) 476-489 PMID: 28487391 | PMCID: PMC5560301

Liu Y, Walavalkar NM, Dozmorov MG, Rich SS, Civelek M, Guertin MJ, Identification of breast cancer associated variants that modulate transcription factor binding., 2017; PLoS genetics. 13(9) e1006761 PMID: 28957321 | PMCID: PMC5619690

Rau CD, Civelek M, Pan C, Lusis AJ, A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel., 2016; Methods in molecular biology (Clifton, N.J.). 1488() 153-188 PMID: 27933524 | PMCID: PMC6615944

Dennis J, Truong V, A?ssi D, Medina-Rivera A, Blankenberg S, Germain M, Lemire M, Antounians L, Civelek M, Schnabel R, Wells P, Wilson MD, Morange PE, Tr?gou?t DA, Gagnon F, Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism., 2016; Journal of thrombosis and haemostasis : JTH. 14(10) 1960-1970 PMID: 27490645 | PMCID: PMC6544906

Touat-Hamici Z, Weidmann H, Blum Y, Proust C, Durand H, Iannacci F, Codoni V, Gaignard P, Th?rond P, Civelek M, Karabina SA, Lusis AJ, Cambien F, Ninio E, Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function., 2016; Cardiovascular research. 112(3) 702-713 PMID: 27694435 | PMCID: PMC5157138

Codoni V, Blum Y, Civelek M, Proust C, Franz?n O, Bj?rkegren JL, Le Goff W, Cambien F, Lusis AJ, Tr?gou?t DA, Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans., 2016; G3 (Bethesda, Md.). 6(10) 3361-3371 PMID: 27558669 | PMCID: PMC5068955

Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franz?n O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skogsberg J, Michoel T, Bj?rkegren JL, Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease., 2016; Cell systems. 2(3) 196-208 PMID: 27135365 | PMCID: PMC4855300

Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtim?ki T, Raitoharju E, K?h?nen M, Sepp?l? I, Raitakari OT, Kuusisto J, Laakso M, Price AL..., Integrative approaches for large-scale transcriptome-wide association studies., 2016; Nature genetics. 48(3) 245-52 PMID: 26854917 | PMCID: PMC4767558

Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J, The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits., 2016; Journal of lipid research. 57(6) 925-42 PMID: 27099397 | PMCID: PMC4878195

Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Sevag Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ, Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains., 2016; PLoS genetics. 12(3) e1005913 PMID: 26934746 | PMCID: PMC4775237

Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin NO, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, Jo H, Fang Y, Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces., 2015; Circulation research. 117(4) e41-53 PMID: 26034042 | PMCID: PMC4522239

Kenagy RD, Civelek M, Kikuchi S, Chen L, Grieff A, Sobel M, Lusis AJ, Clowes AW, Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency., 2015; Journal of vascular surgery. 64(1) 202-209.e6 PMID: 25935274 | PMCID: PMC4627903

Bahn JH, Ahn J, Lin X, Zhang Q, Lee JH, Civelek M, Xiao X, Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways., 2015; Nature communications. 6() 6355 PMID: 25751603 | PMCID: PMC4355961

Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Civelek M, Lusis AJ, Gaulton KJ, Sethupathy P, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke ..., Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol., 2015; American journal of human genetics. 97(6) 801-15 PMID: 26637976 | PMCID: PMC4678431

Germain M, Chasman DI, de Haan H, Tang W, Lindstr?m S, Weng LC, de Andrade M, de Visser MC, Wiggins KL, Suchon P, Saut N, Smadja DM, Le Gal G, van Hylckama Vlieg A, Di Narzo A, Hao K, Nelson CP, Rocanin-Arjo A, Folkersen L, Monajemi R, Rose LM, Br..., Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism., 2015; American journal of human genetics. 96(4) 532-42 PMID: 25772935 | PMCID: PMC4385184

Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ, Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains., 2015; PLoS genetics. 11(12) e1005711 PMID: 26694027 | PMCID: PMC4687930

Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, Navab M, Berliner JA, Iruela-Arispe ML, Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis., 2015; The Journal of experimental medicine. 212(12) 2147-63 PMID: 26552708 | PMCID: PMC4647265

Br?nne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H, Hamby SE, Zeng L, Tr?gou?t DA, Hao K, Topol EJ, Schadt EE, Yang X, Samani NJ, Bj?rkegren JL, Erdmann J, Schunkert H, Lusis AJ, Prediction of Causal Candidate Genes in Coronary Artery Disease Loci., 2015; Arteriosclerosis, thrombosis, and vascular biology. 35(10) 2207-17 PMID: 26293461 | PMCID: PMC4583353

Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito JR, Emmett MJ, Briggs ER, Fang B, Everett LJ, Lim HW, Won KJ, Steger DJ, Wu Y, Civelek M, Voight BF, Lazar MA, Genetic Variation Determines PPAR? Function and Anti-diabetic Drug Response In Vivo., 2015; Cell. 162(1) 33-44 PMID: 26140591 | PMCID: PMC4493773

Romay MC, Che N, Becker SN, Pouldar D, Hagopian R, Xiao X, Lusis AJ, Berliner JA, Civelek M, Regulation of NF-?B signaling by oxidized glycerophospholipid and IL-1? induced miRs-21-3p and -27a-5p in human aortic endothelial cells., 2014; Journal of lipid research. 56(1) 38-50 PMID: 25327529 | PMCID: PMC4274069

Germain M, Pezzolesi MG, Sandholm N, McKnight AJ, Susztak K, Lajer M, Forsblom C, Marre M, Parving HH, Rossing P, Toppila I, Skupien J, Roussel R, Ko YA, Ledo N, Folkersen L, Civelek M, Maxwell AP, Tregouet DA, Groop PH, Tarnow L, Hadjadj S, SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes., 2014; Diabetologia. 58(3) 543-8 PMID: 25476525 |

Civelek M, Lusis AJ, From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis., 2014; Arteriosclerosis, thrombosis, and vascular biology. 34(9) 1809-10 PMID: 25142882 | PMCID: PMC4142522

Iatan I, Choi HY, Ruel I, Reddy MV, Kil H, Lee J, Odeh MA, Salah Z, Abu-Remaileh M, Weissglas-Volkov D, Nikkola E, Civelek M, Awan Z, Croce CM, Aqeilan RI, Pajukanta P, Aldaz CM, Genest J, The WWOX gene modulates high-density lipoprotein and lipid metabolism., 2014; Circulation. Cardiovascular genetics. 7(4) 491-504 PMID: 24871327 | PMCID: PMC4315188

M?kinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segr? AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, Blakenberg S, O'Donnell CJ, M?rz W, Laaksonen R, Epstein SE, Kathiresan S, Shah SH, Hazen SL, Re..., Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease., 2014; PLoS genetics. 10(7) e1004502 PMID: 25033284 | PMCID: PMC4102418

Civelek M, Lusis AJ, Systems genetics approaches to understand complex traits., 2013; Nature reviews. Genetics. 15(1) 34-48 PMID: 24296534 | PMCID: PMC3934510

Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis AJ, Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice., 2013; Cell metabolism. 17(1) 141-52 PMID: 23312289 | PMCID: PMC3545283

de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Bald?n ?, Esau C, Edwards PA, MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor., 2013; Circulation research. 112(12) 1602-12 PMID: 23519696 | PMCID: PMC3995747

Erbilgin A, Civelek M, Romanoski CE, Pan C, Hagopian R, Berliner JA, Lusis AJ, Identification of CAD candidate genes in GWAS loci and their expression in vascular cells., 2013; Journal of lipid research. 54(7) 1894-905 PMID: 23667179 | PMCID: PMC3679391

Davies PF, Civelek M, Fang Y, Fleming I, The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo., 2013; Cardiovascular research. 99(2) 315-27 PMID: 23619421 | PMCID: PMC3695748

Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ, Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits., 2013; Human molecular genetics. 22(15) 3023-37 PMID: 23562819 | PMCID: PMC3699064

Mahendran Y, Vangipurapu J, Cederberg H, Stanc?kov? A, Pihlajam?ki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M, Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men., 2013; Diabetes. 62(10) 3618-26 PMID: 23557707 | PMCID: PMC3781437

Stanc?kov? A, Civelek M, Saleem NK, Soininen P, Kangas AJ, Cederberg H, Paananen J, Pihlajam?ki J, Bonnycastle LL, Morken MA, Boehnke M, Pajukanta P, Lusis AJ, Collins FS, Kuusisto J, Ala-Korpela M, Laakso M, Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men., 2012; Diabetes. 61(7) 1895-902 PMID: 22553379 | PMCID: PMC3379649

Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, O..., Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits., 2012; Mammalian genome : official journal of the International Mammalian Genome Society. 23(9) 680-92 PMID: 22892838 | PMCID: NIHMS416512

Haas BE, Horvath S, Pietil?inen KH, Cantor RM, Nikkola E, Weissglas-Volkov D, Rissanen A, Civelek M, Cruz-Bautista I, Riba L, Kuusisto J, Kaprio J, Tusie-Luna T, Laakso M, Aguilar-Salinas CA, Pajukanta P, Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes., 2012; BMC medical genomics. 5() 61 PMID: 23217153 | PMCID: PMC3543280

Kim JB, Deluna A, Mungrue IN, Vu C, Pouldar D, Civelek M, Orozco L, Wu J, Wang X, Charugundla S, Castellani LW, Rusek M, Jakubowski H, Jakobowski H, Lusis AJ, Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice., 2012; Circulation. 126(15) 1896-906 PMID: 22952318 | PMCID: PMC3608429

Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Davies PF, Coronary artery endothelial transcriptome in vivo: identification of endoplasmic reticulum stress and enhanced reactive oxygen species by gene connectivity network analysis., 2011; Circulation. Cardiovascular genetics. 4(3) 243-52 PMID: 21493819 | PMCID: PMC3116084

Romanoski CE, Che N, Yin F, Mai N, Pouldar D, Civelek M, Pan C, Lee S, Vakili L, Yang WP, Kayne P, Mungrue IN, Araujo JA, Berliner JA, Lusis AJ, Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1., 2011; Circulation research. 109(5) e27-41 PMID: 21737788 | PMCID: PMC3163234

Civelek M, Lusis AJ, Conducting the metabolic syndrome orchestra., 2011; Nature genetics. 43(6) 506-8 PMID: 21614088 | PMCID: PMC3934506

Civelek M, Manduchi E, Grant GR, Stoeckert CJ, Davies PF, Discovery approaches to UPR in athero-susceptible endothelium in vivo., 2011; Methods in enzymology. 489() 109-26 PMID: 21266227 | PMCID: PMC3833809

Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG, Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo., 2010; Seminars in thrombosis and hemostasis. 36(3) 265-75 PMID: 20533180 | PMCID: PMC3817717

Fang Y, Shi C, Manduchi E, Civelek M, Davies PF, MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro., 2010; Proceedings of the National Academy of Sciences of the United States of America. 107(30) 13450-5 PMID: 20624982 | PMCID: PMC2922125

Davies PF, Civelek M, Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress., 2010; Antioxidants & redox signaling. 15(5) 1427-32 PMID: 21126204 | PMCID: PMC3144426

Civelek M, Grant GR, Irolla CR, Shi C, Riley RJ, Chiesa OA, Stoeckert CJ, Karanian JW, Pritchard WF, Davies PF, Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo., 2009; American journal of physiology. Heart and circulatory physiology. 298(1) H163-70 PMID: 19897713 | PMCID: PMC2806137

Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Davies PF, Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis., 2009; Circulation research. 105(5) 453-61 PMID: 19661457 | PMCID: PMC2746924

Civelek M, Ainslie K, Garanich JS, Tarbell JM, Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism., 2002; Journal of applied physiology (Bethesda, Md. : 1985). 93(6) 1907-17 PMID: 12391063 |

Sharma R, Yellowley CE, Civelek M, Ainslie K, Hodgson L, Tarbell JM, Donahue HJ, Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow., 2002; Annals of biomedical engineering. 30(3) 371-8 PMID: 12051621 | PMCID: PMC4472337