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Erickson, Loren

Loren Erickson

Primary Appointment

Microbiology, Immunology, and Cancer Biology

Contact Information

MR-6 2704
Charlottesville, VA 22908
Telephone: 434-982-0756
Fax: 434-924-1221
Email: lde9w@virginia.edu
Website: https://med.virginia.edu/faculty/faculty-listing/lde9w/

Research Interests

Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders

Research Description

CURRENT PROJECTS: - Using mouse genetics to identify the susceptibility factors that control B cell tolerance, differentiation and survival, leading to autoantibody production. - Defining the mechanisms by which autoimmune susceptibility elicits inflammation and recruitment of innate immune cells in secondary lymphoid organs that affect B cell function. - Examining helper activity and inflammatory cytokines of human T cells in peripheral blood of SLE patients that affect B cell function. - Characterizing the regulation and activity in primary mouse T follicular helper cells and T follicular regulatory cells to control B cell responses. - Defining the signal transduction events through the BCMA cytokine receptor that regulates both T follicular helper cell homeostasis and plasma cell survival in autoimmunity. - Characterizing the development and persistence of IgE antibodies to airway allergens.

Selected Publications

Coquery CM, Wade NS, Loo WM, Kinchen JM, Cox KM, Jiang C, Tung KS, Erickson LD, Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice., 2014; PloS one. 9(7) e102284 PMID: 25010693 | PMCID: PMC4092127

Coquery CM, Loo WM, Wade NS, Bederman AG, Tung KS, Lewis JE, Hess H, Erickson LD, BAFF regulates T follicular helper cells and affects accumulation and IFN? production in autoimmunity., 2014; Arthritis & rheumatology (Hoboken, N.J.). () PMID: 25385309 | PMCID: PMC4342294

Peperzak V, Vikstr?m I, Walker J, Glaser SP, LePage M, Coquery CM, Erickson LD, Fairfax K, Mackay F, Strasser A, Nutt SL, Tarlinton DM, Mcl-1 is essential for the survival of plasma cells., 2013; Nature immunology. 14(3) 290-7 PMID: 23377201 | PMCID: PMC4041127

Coquery CM, Erickson LD, Regulatory roles of the tumor necrosis factor receptor BCMA., 2012; Critical reviews in immunology. 32(4) 287-305 PMID: 23237506 | PMCID: PMC3548317

Coquery CM, Loo W, Buszko M, Lannigan J, Erickson LD, Optimized protocol for the isolation of spleen-resident murine neutrophils., 2012; Cytometry. Part A : the journal of the International Society for Analytical Cytology. 81(9) 806-14 PMID: 22760952 | PMCID: PMC3548322

Panchanathan R, Liu H, Liu H, Fang CM, Erickson LD, Pitha PM, Choubey D, Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis., 2011; Journal of immunology (Baltimore, Md. : 1950). 188(1) 270-8 PMID: 22116829 | PMCID: PMC3244553

Wolf AI, Mozdzanowska K, Quinn WJ, Metzgar M, Williams KL, Caton AJ, Meffre E, Bram RJ, Erickson LD, Allman D, Cancro MP, Erikson J, Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI., 2011; The Journal of clinical investigation. 121(10) 3954-64 PMID: 21881204 | PMCID: PMC3195469

Panchanathan R, Shen H, Duan X, Rathinam VA, Erickson LD, Fitzgerald KA, Choubey D, Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein., 2011; Journal of immunology (Baltimore, Md. : 1950). 186(12) 6762-70 PMID: 21551362 | PMCID: PMC3110550

Ernst PB, Erickson LD, Loo WM, Scott KG, Wiznerowicz EB, Brown CC, Torres-Velez FJ, Alam MS, Black SG, McDuffie M, Feldman SH, Wallace JL, McKnight GW, Padol IT, Hunt RH, Tung KS, Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice., 2011; American journal of physiology. Gastrointestinal and liver physiology. 302(1) G105-15 PMID: 21921286 | PMCID: PMC3345967

Jiang C, Loo WM, Greenley EJ, Tung KS, Erickson LD, B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus., 2011; Journal of immunology (Baltimore, Md. : 1950). 186(11) 6136-47 PMID: 21536804 | PMCID: PMC3181142

Panchanathan R, Duan X, Shen H, Rathinam VA, Erickson LD, Fitzgerald KA, Choubey D, Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus., 2010; Journal of immunology (Baltimore, Md. : 1950). 185(12) 7385-93 PMID: 21057088 | PMCID: PMC3059233

J?rgensen TN, Alfaro J, Enriquez HL, Jiang C, Loo WM, Atencio S, Bupp MR, Mailloux CM, Metzger T, Flannery S, Rozzo SJ, Kotzin BL, Rosemblatt M, Bono MR, Erickson LD, Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus., 2009; Journal of immunology (Baltimore, Md. : 1950). 184(2) 775-86 PMID: 20018631 | PMCID: PMC2841050

Khuda SE, Loo WM, Janz S, Van Ness B, Erickson LD, Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors., 2008; Journal of immunology (Baltimore, Md. : 1950). 181(11) 7537-49 PMID: 19017943 | PMCID: PMC2841033

Benson MJ, Erickson LD, Gleeson MW, Noelle RJ, Affinity of antigen encounter and other early B-cell signals determine B-cell fate., 2007; Current opinion in immunology. 19(3) 275-80 PMID: 17433651 | PMCID: PMC2827202

O'Connor BP, Vogel LA, Zhang W, Loo W, Shnider D, Lind EF, Ratliff M, Noelle RJ, Erickson LD, Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor., 2006; Journal of immunology (Baltimore, Md. : 1950). 177(11) 7723-32 PMID: 17114443 | PMCID: PMC2819292

Noelle RJ, Erickson LD, Determinations of B cell fate in immunity and autoimmunity., 2004; Current directions in autoimmunity. 8() 1-24 PMID: 15564715 |

O'Connor BP, Raman VS, Erickson LD, Cook WJ, Weaver LK, Ahonen C, Lin LL, Mantchev GT, Bram RJ, Noelle RJ, BCMA is essential for the survival of long-lived bone marrow plasma cells., 2004; The Journal of experimental medicine. 199(1) 91-8 PMID: 14707116 | PMCID: PMC1887725

Erickson LD, Lin LL, Duan B, Morel L, Noelle RJ, A genetic lesion that arrests plasma cell homing to the bone marrow., 2003; Proceedings of the National Academy of Sciences of the United States of America. 100(22) 12905-10 PMID: 14555759 | PMCID: PMC240717

O'Connor BP, Gleeson MW, Noelle RJ, Erickson LD, The rise and fall of long-lived humoral immunity: terminal differentiation of plasma cells in health and disease., 2003; Immunological reviews. 194() 61-76 PMID: 12846808 | PMCID: PMC2827865

Erickson LD, Durell BG, Vogel LA, O'Connor BP, Cascalho M, Yasui T, Kikutani H, Noelle RJ, Short-circuiting long-lived humoral immunity by the heightened engagement of CD40., 2002; The Journal of clinical investigation. 109(5) 613-20 PMID: 11877469 | PMCID: PMC150892

Ahonen C, Manning E, Erickson LD, O'Connor B, Lind EF, Pullen SS, Kehry MR, Noelle RJ, The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells., 2002; Nature immunology. 3(5) 451-6 PMID: 11967542 | PMCID: PMC2834483

Erickson LD, Foy TM, Waldschmidt TJ, Murine B1 B cells require IL-5 for optimal T cell-dependent activation., 2001; Journal of immunology (Baltimore, Md. : 1950). 166(3) 1531-9 PMID: 11160193 | PMCID: PMC2832833

Erickson LD, Vogel LA, Cascalho M, Wong J, Wabl M, Durell BG, Noelle RJ, B cell immunopoiesis: visualizing the impact of CD40 engagement on the course of T cell-independent immune responses in an Ig transgenic system., 2000; European journal of immunology. 30(11) 3121-31 PMID: 11093126 | PMCID: PMC2827196

Erickson LD, Tygrett LT, Bhatia SK, Grabstein KH, Waldschmidt TJ, Differential expression of CD22 (Lyb8) on murine B cells., 1996; International immunology. 8(7) 1121-9 PMID: 8757957 | PMCID: PMC2859887