Primary AppointmentMicrobiology, Immunology, and Cancer Biology
Charlottesville, VA 22908
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
CURRENT PROJECTS: - Using mouse genetics to identify the susceptibility factors that control B cell tolerance, differentiation and survival, leading to autoantibody production. - Defining the mechanisms by which autoimmune susceptibility elicits inflammation and recruitment of innate immune cells in secondary lymphoid organs that affect B cell function. - Characterizing the regulation and activity of extracellular vesicles derived from B cells to control autoimmune responses. - Characterizing the development and persistence of IgE antibodies to food allergens using red meat allergy as a model system.