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Hsu, Ku-Lung

Ku-Lung Hsu

Primary Appointment


Contact Information

McCormick Road
Charlottesville, VA 22904
Telephone: 434-297-4864

Research Interests

Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry

Research Description

Professor Hsu is an Assistant Professor in the Departments of Chemistry and Pharmacology at the University of Virginia. The Hsu Lab is focused on developing chemical methods and probes to address fundamental challenges associated with studying regulation of metabolism and signaling in vivo. Current efforts are focused on discovery of new lipid metabolic targets for chronic inflammation and immuno-oncology. Members of the Hsu Lab receive cross-disciplinary training in chemical biology, mass spectrometry, medicinal chemistry, and in vivo pharmacology. Professor Hsu is a recipient of several awards including the highly competitive NIH K99/R00 Pathway to Independence Award, DOD CDMRP Career Development Award, a Young Investigator Award from the Melanoma Research Alliance (MRA), and the NSF CAREER Award.

Selected Publications

Ware TB, Franks CE, Granade ME, Zhang M, Kim KB, Park KS, Gahlmann A, Harris TE, Hsu KL, Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering., 2020; Nature chemical biology. () PMID: 31932721 |

Shin M, Buckner A, Prince J, Bullock TNJ, Hsu KL, Diacylglycerol Lipase-? Is Required for TNF-? Response but Not CD8+ T Cell Priming Capacity of Dendritic Cells., 2019; Cell chemical biology. () PMID: 31105063 | PMCID: PMC6641989

Hahm HS, Toroitich EK, Borne AL, Brulet JW, Libby AH, Yuan K, Ware TB, McCloud RL, Ciancone AM, Hsu KL, Global targeting of functional tyrosines using sulfur-triazole exchange chemistry., 2019; Nature chemical biology. () PMID: 31768034 |

Shin M, Franks CE, Hsu KL, Isoform-selective activity-based profiling of ERK signaling., 2018; Chemical science. 9(9) 2419-2431 PMID: 29732117 | PMCID: PMC5909473

Shin M, Snyder HW, Donvito G, Schurman LD, Fox TE, Lichtman AH, Kester M, Hsu KL, Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo., 2017; Molecular pharmaceutics. () PMID: 28901776 |

McCloud RL, Franks CE, Campbell ST, Purow BW, Harris TE, Hsu KL, Deconstructing Lipid Kinase Inhibitors by Chemical Proteomics., 2017; Biochemistry. () PMID: 29155586 |

Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu KL, Cravatt BF, Selective Inhibitor of Platelet-Activating Factor Acetylhydrolases 1b2 and 1b3 That Impairs Cancer Cell Survival., 2015; ACS chemical biology. () PMID: 25602368 |

Inloes JM, Hsu KL, Dix MM, Viader A, Masuda K, Takei T, Wood MR, Cravatt BF, The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase., 2014; Proceedings of the National Academy of Sciences of the United States of America. 111(41) 14924-9 PMID: 25267624 | PMCID: PMC4205627

Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF, Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis., 2013; Journal of medicinal chemistry. 56(21) 8257-69 PMID: 24152245 | PMCID: PMC3984011

Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF, Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of ?/?-hydrolase domain containing 6 (ABHD6)., 2013; Journal of medicinal chemistry. 56(21) 8270-9 PMID: 24152295 | PMCID: PMC3987869

Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF, DAGL? inhibition perturbs a lipid network involved in macrophage inflammatory responses., 2012; Nature chemical biology. 8(12) 999-1007 PMID: 23103940 | PMCID: PMC3513945