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Kapur, Jaideep

Jaideep Kapur

Primary Appointment

Neurology

Contact Information

Telephone: 924-5312
Email: jk8t@virginia.edu

Research Interests

Pathophysiology of Status Epilepticus; Mechanisms and pathways of seizure spread

Research Description

1) Mapping circuits that sustain prolonged seizures using genetically modified animals, clarity and imaging. 2) Role of AMPA receptor plasticity in seizure spread. 3) Progesterone modulation of seizures and hippocampal excitability. 4) Mechanisms and treatment of neonatal seizures.

Selected Publications

Joshi S, Rajasekaran K, Sun H, Williamson J, Kapur J, Enhanced AMPA receptor-mediated neurotransmission on CA1 pyramidal neurons during status epilepticus., 2017; Neurobiology of disease. 103() 45-53 PMID: 28377128 |

Wychowski T, Kapur J, Isocitrate dehydrogenase mutations: A biomarker for glioma-related excitability and seizures., 2017; Neurology. () PMID: 28404804 |

Schomer AC, Kapur J, The SAMUKeppra study in prehospital status epilepticus: lessons for future study., 2017; Annals of translational medicine. 4(23) 468 PMID: 28090524 | PMCID: PMC5220030

Zanelli SA, Rajasekaran K, Grosenbaugh DK, Kapur J, Increased excitability and excitatory synaptic transmission during in vitro ischemia in the neonatal mouse hippocampus., 2015; Neuroscience. 310() 279-89 PMID: 26404876 | PMCID: PMC4635675

Johnson SE, Hudson JL, Kapur J, Synchronization of action potentials during low-magnesium-induced bursting., 2015; Journal of neurophysiology. 113(7) 2461-70 PMID: 25609103 | PMCID: PMC4416584

Zanelli S, Goodkin HP, Kowalski S, Kapur J, Impact of transient acute hypoxia on the developing mouse EEG., 2014; Neurobiology of disease. 68() 37-46 PMID: 24636798 |

Bleck T, Cock H, Chamberlain J, Cloyd J, Connor J, Elm J, Fountain N, Jones E, Lowenstein D, Shinnar S, Silbergleit R, Treiman D, Trinka E, Kapur J, The established status epilepticus trial 2013., 2013; Epilepsia. 54() 89-92 PMID: 24001084 | PMCID: PMC4048827

Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E, A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus., 2013; Epilepsia. 55(2) 203-13 PMID: 24299204 | PMCID: PMC4161023

Pitk?nen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, L?scher W, Mody I, Schmidt D, Issues related to development of antiepileptogenic therapies., 2013; Epilepsia. 54() 35-43 PMID: 23909852 | PMCID: PMC3740390

Joshi S, Keith KJ, Ilyas A, Kapur J, GABAA receptor membrane insertion rates are specified by their subunit composition., 2013; Molecular and cellular neurosciences. 56() 201-11 PMID: 23714576 | PMCID: PMC3791162

Berkovic SF, Kapur J, Are myotonia and epilepsy linked by a chloride channel?, 2013; Neurology. 80(12) 1074-5 PMID: 23408869 |

Joshi S, Kapur J, N-methyl-D-aspartic acid receptor activation downregulates expression of ? subunit-containing GABAA receptors in cultured hippocampal neurons., 2013; Molecular pharmacology. 84(1) 1-11 PMID: 23585058 | PMCID: PMC3684822

Kozhemyakin M, Rajasekaran K, Todorovic MS, Kowalski SL, Balint C, Kapur J, Somatostatin type-2 receptor activation inhibits glutamate release and prevents status epilepticus., 2013; Neurobiology of disease. 54() 94-104 PMID: 23473742 | PMCID: PMC3628955

Sun C, Sun J, Erisir A, Kapur J, Loss of cholecystokinin-containing terminals in temporal lobe epilepsy., 2013; Neurobiology of disease. 62() 44-55 PMID: 24051276 | PMCID: PMC3877730

Todorovic MS, Cowan ML, Balint CA, Sun C, Kapur J, Characterization of status epilepticus induced by two organophosphates in rats., 2012; Epilepsy research. 101(3) 268-76 PMID: 22578704 | PMCID: PMC3419801

Rusin CG, Johnson SE, Kapur J, Hudson JL, Engineering the synchronization of neuron action potentials using global time-delayed feedback stimulation., 2012; Physical review. E, Statistical, nonlinear, and soft matter physics. 84(6) 066202 PMID: 22304173 |

Sun J, Kapur J, M-type potassium channels modulate Schaffer collateral-CA1 glutamatergic synaptic transmission., 2012; The Journal of physiology. 590(0) 3953-64 PMID: 22674722 | PMCID: PMC3476642

Rajasekaran K, Todorovic M, Kapur J, Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus., 2012; Annals of neurology. 72(1) 91-102 PMID: 22829271 | PMCID: PMC3408623

Joshi S, Rajasekaran K, Kapur J, GABAergic transmission in temporal lobe epilepsy: the role of neurosteroids., 2011; Experimental neurology. 244() 36-42 PMID: 22101060 | PMCID: PMC3319002

Rannals MD, Kapur J, Homeostatic strengthening of inhibitory synapses is mediated by the accumulation of GABA(A) receptors., 2011; The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(48) 17701-12 PMID: 22131430 | PMCID: PMC3396123

Rajasekaran K, Joshi S, Sun C, Mtchedlishvilli Z, Kapur J, Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals., 2010; Neurobiology of disease. 40(2) 490-501 PMID: 20682339 | PMCID: PMC2940226

Lawrence C, Martin BS, Sun C, Williamson J, Kapur J, Endogenous neurosteroid synthesis modulates seizure frequency., 2010; Annals of neurology. 67(5) 689-93 PMID: 20437568 | PMCID: PMC2918659

Goodkin HP, Joshi S, Mtchedlishvili Z, Brar J, Kapur J, Subunit-specific trafficking of GABA(A) receptors during status epilepticus., 2008; The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(10) 2527-38 PMID: 18322097 | PMCID: PMC2880323

Rajasekaran K, Kapur J, Bertram EH, Alterations in GABA(A) receptor mediated inhibition in adjacent dorsal midline thalamic nuclei in a rat model of chronic limbic epilepsy., 2007; Journal of neurophysiology. 98(5) 2501-8 PMID: 17855591 |

Sun C, Mtchedlishvili Z, Erisir A, Kapur J, Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy., 2007; The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(46) 12641-50 PMID: 18003843 | PMCID: PMC2878477

Martin BS, Kapur J, A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation., 2007; Epilepsia. 49(2) 248-55 PMID: 17941842 | PMCID: PMC2844443

Swanwick CC, Murthy NR, Mtchedlishvili Z, Sieghart W, Kapur J, Development of gamma-aminobutyric acidergic synapses in cultured hippocampal neurons., 2006; The Journal of comparative neurology. 495(5) 497-510 PMID: 16498682 | PMCID: PMC2742963

Trotter SA, Kapur J, Anzivino MJ, Lee KS, GABAergic synaptic inhibition is reduced before seizure onset in a genetic model of cortical malformation., 2006; The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(42) 10756-67 PMID: 17050714 |

Sun C, Mtchedlishvili Z, Bertram EH, Erisir A, Kapur J, Selective loss of dentate hilar interneurons contributes to reduced synaptic inhibition of granule cells in an electrical stimulation-based animal model of temporal lobe epilepsy., 2006; The Journal of comparative neurology. 500(5) 876-93 PMID: 17177260 | PMCID: PMC2844442