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Hossack, John

John Hossack

Primary Appointment

Biomedical Engineering

Contact Information

Telephone: 434-243-5866
Email: jh7fj@virginia.edu
Website: http://www.faculty.virginia.edu/hossack/

Research Interests

Diagnostic ultrasound - image processing, quantification Molecular imaging using ultrasound Catheter-based ultrasound Ultrasound-based drug/gene delivery Ultrasound image guided therapy

Research Description

Diagnostic ultrasound - image processing, quantification Molecular imaging using ultrasound Catheter-based ultrasound Ultrasound-based drug/gene delivery Ultrasound image guided therapy

Selected Publications

Wang S, Dhanaliwala AH, Chen JL, Hossack JA, Production rate and diameter analysis of spherical monodisperse microbubbles from two-dimensional, expanding-nozzle flow-focusing microfluidic devices., 2014; Biomicrofluidics. 7(1) 14103 PMID: 24403995 | PMCID: PMC3562342

Wang S, Mauldin FW, Klibanov AL, Hossack JA, Shear forces from flow are responsible for a distinct statistical signature of adherent microbubbles in large vessels., 2013; Molecular imaging. 12(6) 396-408 PMID: 23981785 | PMCID: PMC4061764

Dixon AJ, Dhanaliwala AH, Chen JL, Hossack JA, Enhanced intracellular delivery of a model drug using microbubbles produced by a microfluidic device., 2013; Ultrasound in medicine & biology. 39(7) 1267-76 PMID: 23643062 | PMCID: PMC3674153

Mauldin FW, Dhanaliwala AH, Patil AV, Hossack JA, Real-time targeted molecular imaging using singular value spectra properties to isolate the adherent microbubble signal., 2012; Physics in medicine and biology. 57(16) 5275-93 PMID: 22853933 | PMCID: PMC3440015

Li Y, Garson CD, Xu Y, Helm PA, Hossack JA, French BA, Serial ultrasound evaluation of intramyocardial strain after reperfused myocardial infarction reveals that remote zone dyssynchrony develops in concert with left ventricular remodeling., 2011; Ultrasound in medicine & biology. 37(7) 1073-86 PMID: 21640480 | PMCID: PMC3119373

Patil AV, Rychak JJ, Klibanov AL, Hossack JA, Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results., 2011; Molecular imaging. 10(4) 238-47 PMID: 21521555 | PMCID: PMC3127411

Phillips LC, Klibanov AL, Wamhoff BR, Hossack JA, Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation., 2011; Journal of controlled release : official journal of the Controlled Release Society. 154(1) 42-9 PMID: 21549778 | PMCID: PMC3148278

Tlaxca JL, Anderson CR, Klibanov AL, Lowrey B, Hossack JA, Alexander JS, Lawrence MB, Rychak JJ, Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles., 2010; Ultrasound in medicine & biology. 36(11) 1907-18 PMID: 20800945 | PMCID: PMC2996233

Phillips LC, Klibanov AL, Wamhoff BR, Hossack JA, Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery., 2010; Ultrasound in medicine & biology. 36(9) 1470-80 PMID: 20800174 | PMCID: PMC2930891

Patil AV, Rychak JJ, Allen JS, Klibanov AL, Hossack JA, Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels., 2009; Ultrasound in medicine & biology. 35(12) 2021-30 PMID: 19828229 | PMCID: PMC2790010

Phillips LC, Klibanov AL, Bowles DK, Ragosta M, Hossack JA, Wamhoff BR, Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles., 2009; Journal of vascular research. 47(3) 270-4 PMID: 19923850 | PMCID: PMC2865392

Song J, Klibanov AL, Hossack JA, Price RJ, Acoustic attenuation by contrast agent microbubbles in superficial tissue markedly diminishes petechiae bioeffects in deep tissue., 2008; Investigative radiology. 43(5) 322-9 PMID: 18424953 | PMCID: PMC2714264

French BA, Li Y, Klibanov AL, Yang Z, Hossack JA, 3D perfusion mapping in post-infarct mice using myocardial contrast echocardiography., 2006; Ultrasound in medicine & biology. 32(6) 805-15 PMID: 16785003 |