Mobile Menu Button

Casanova, James

James Casanova

Primary Appointment

Cell Biology

Contact Information

Dept. of Cell Biology
Charlottesville, VA 22908-0732
Telephone: 434-243-4821
Email: jec9e@virginia.edu

Research Interests

Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.

Research Description

Arf family GTPases and their function in membrane trafficking and cell motility
Cell biology of bacterial infection
The innate immune response to bacterial infection

Selected Publications

Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Sch?rmann A, Wilhelmi I, Yohe ME, Kahn RA, ARF GTPases and their GEFs and GAPs: concepts and challenges., 2019; Molecular biology of the cell. 30(11) 1249-1271 PMID: 31084567 |

Thomas KS, Owen KA, Conger K, Llewellyn RA, Bouton AH, Casanova JE, Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair., 2019; Scientific reports. 9(1) 4497 PMID: 30872746 | PMCID: PMC6418130

Casanova JE, Bacterial Autophagy: Offense and Defense at the Host-Pathogen Interface., 2017; Cellular and molecular gastroenterology and hepatology. 4(2) 237-243 PMID: 28660242 | PMCID: PMC5480303

Billings EA, Lee CS, Owen KA, D'Souza RS, Ravichandran KS, Casanova JE, The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria., 2016; Science signaling. 9(413) ra14 PMID: 26838550 | PMCID: PMC4894535

Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB, ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome., 2016; Cellular and molecular gastroenterology and hepatology. 1(3) 311-324 PMID: 26878033 | PMCID: PMC4747049

Owen KA, Anderson CJ, Casanova JE, Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in Macrophages., 2016; mBio. 7(1) e02051-15 PMID: 26884434 | PMCID: PMC4791850

D'Souza RS, Casanova JE, The BRAG/IQSec family of Arf GEFs., 2016; Small GTPases. 7(4) 257-264 PMID: 27739918 | PMCID: PMC5129896

Simmons JA, D'Souza RS, Ruas M, Galione A, Casanova JE, White JM, Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes., 2015; Journal of virology. 90(1) 605-10 PMID: 26468524 | PMCID: PMC4702577

Owen KA, Casanova JE, Salmonella Manipulates Autophagy to "Serve and Protect"., 2015; Cell host & microbe. 18(5) 517-9 PMID: 26567504 |

Mingo RM, Simmons JA, Shoemaker CJ, Nelson EA, Schornberg KL, D'Souza RS, Casanova JE, White JM, Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step., 2015; Journal of virology. 89(5) 2931-43 PMID: 25552710 | PMCID: PMC4325712

D'Souza RS, Semus R, Billings EA, Meyer CB, Conger K, Casanova JE, Rab4 Orchestrates a Small GTPase Cascade for Recruitment of Adaptor Proteins to Early Endosomes., 2014; Current biology : CB. 24(11) 1187-98 PMID: 24835460 | PMCID: PMC4059052

Owen KA, Meyer CB, Bouton AH, Casanova JE, Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages., 2014; PLoS pathogens. 10(6) e1004159 PMID: 24901456 | PMCID: PMC4047085

Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters KN, Paraoan L, Casanova JE, Boll EJ, McCormick BA, PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation., 2014; Cellular microbiology. 17(6) 843-59 PMID: 25486861 |

Casanova JE, Hsu VW, Jackson CL, Kahn RA, Roy CR, Stow JL, Wandinger-Ness A, Sztul E, Meeting report - Arf and Rab family G proteins., 2013; Journal of cell science. 126(0) 5313-6 PMID: 24293329 |

Moravec R, Conger KK, D'Souza R, Allison AB, Casanova JE, BRAG2/GEP100/IQSec1 Interacts with Clathrin and Regulates ?5?1 Integrin Endocytosis through Activation of ADP Ribosylation Factor 5 (Arf5)., 2012; The Journal of biological chemistry. 287(37) 31138-47 PMID: 22815487 | PMCID: PMC3438945

Myers KR, Wang G, Sheng Y, Conger KK, Casanova JE, Zhu JJ, Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder., 2012; The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(34) 11716-26 PMID: 22915114 | PMCID: PMC3459061

Owen KA, Abshire MY, Tilghman RW, Casanova JE, Bouton AH, FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing., 2011; PloS one. 6(8) e23123 PMID: 21887232 | PMCID: PMC3160839

Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE, Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria., 2011; Proceedings of the National Academy of Sciences of the United States of America. 108(5) 2136-41 PMID: 21245295 | PMCID: PMC3033312

Matto M, Sklan EH, David N, Melamed-Book N, Casanova JE, Glenn JS, Aroeti B, Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication., 2010; Journal of virology. 85(2) 946-56 PMID: 21068255 | PMCID: PMC3020004

Kitt KN, Hern?ndez-Deviez D, Ballantyne SD, Spiliotis ET, Casanova JE, Wilson JM, Rab14 regulates apical targeting in polarized epithelial cells., 2008; Traffic (Copenhagen, Denmark). 9(7) 1218-31 PMID: 18429929 | PMCID: PMC2773667

Myers KR, Casanova JE, Regulation of actin cytoskeleton dynamics by Arf-family GTPases., 2008; Trends in cell biology. 18(4) 184-92 PMID: 18328709 | PMCID: PMC2885709

Ly KT, Casanova JE, Abelson tyrosine kinase facilitates Salmonella enterica serovar Typhimurium entry into epithelial cells., 2008; Infection and immunity. 77(1) 60-9 PMID: 18936177 | PMCID: PMC2612273

Hall B, McLean MA, Davis K, Casanova JE, Sligar SG, Schwartz MA, A fluorescence resonance energy transfer activation sensor for Arf6., 2007; Analytical biochemistry. 374(2) 243-9 PMID: 18162163 | PMCID: PMC2277471

Cuthbert EJ, Davis KK, Casanova JE, Substrate specificities and activities of AZAP family Arf GAPs in vivo., 2007; American journal of physiology. Cell physiology. 294(1) C263-70 PMID: 18003747 |

Balasubramanian N, Scott DW, Castle JD, Casanova JE, Schwartz MA, Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts., 2007; Nature cell biology. 9(12) 1381-91 PMID: 18026091 | PMCID: PMC2715295

Casanova JE, PARtitioning numb., 2007; EMBO reports. 8(3) 233-5 PMID: 17330067 | PMCID: PMC1808048

Ma Z, Nie Z, Luo R, Casanova JE, Ravichandran KS, Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP., 2007; Current biology : CB. 17(8) 722-7 PMID: 17398097 | PMCID: PMC1930157

Yoon HY, Miura K, Cuthbert EJ, Davis KK, Ahvazi B, Casanova JE, Randazzo PA, ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP., 2006; Journal of cell science. 119(0) 4650-66 PMID: 17077126 |

Shi J, Casanova JE, Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas., 2006; Molecular biology of the cell. 17(11) 4698-708 PMID: 16914515 | PMCID: PMC1635395

Casanova JE, There goes the neighborhood. Focus on "localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion"., 2006; American journal of physiology. Cell physiology. 291(2) C231-3 PMID: 16825602 |

Shmuel M, Santy LC, Frank S, Avrahami D, Casanova JE, Altschuler Y, ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells., 2006; The Journal of biological chemistry. 281(19) 13300-8 PMID: 16484220 |

Dunphy JL, Moravec R, Ly K, Lasell TK, Melancon P, Casanova JE, The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins., 2006; Current biology : CB. 16(3) 315-20 PMID: 16461286 | PMCID: NIHMS437917

Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V, V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway., 2006; Nature cell biology. 8(2) 124-36 PMID: 16415858 |