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Woodfolk, Judith

Judith Woodfolk

Primary Appointment

Medicine- Asthma, Allergy and Immunology

Contact Information

Telephone: 434-924-1293 / 434-982-3958
Fax: 434-924-1251
Email: jaw4m@virginia.edu

Research Interests

Cellular and molecular mechanisms of allergic disease in humans.

Research Description

Research in my lab focuses on improving our understanding of how the human immune system responds to environmental triggers of allergic disease. The prevalence of allergic diseases, including asthma, has risen dramatically in the last few decades. Exposure to rhinovirus, the major cause of common cold, is an important risk factor for acute asthma episodes. The primary objective of my work is to gain new insight into cellular mechanisms that promote pathogenic and protective responses to allergens and rhinovirus in humans. Current projects include: (1) Mechanisms of cross-protective adaptive immunity to human rhinovirus in an experimental human infection model; (2) Mechanisms of T-cell dysregulation in rhinovirus-induced asthma; and (3) The role of the TSLP pathway in allergic inflammation. Ongoing work uses novel tools and state-of-the-art technologies to provide a systems biology perspective of immune activation in humans. Our approach involves a high degree of collaboration with clinical specialists in adult and pediatric allergy/respiratory medicine, as well as with basic scientists in the fields of virology, biochemistry, genetics, transcriptomics, and single-cell analytics.

Selected Publications

Muehling LM, Turner RB, Brown KB, Wright PW, Patrie JT, Lahtinen SJ, Lehtinen MJ, Kwok WW, Woodfolk JA, Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans., 2018; The Journal of infectious diseases. 217(3) 381-392 PMID: 29309618 | PMCID: PMC5853408

Wisniewski JA, Muehling LM, Eccles JD, Capaldo BJ, Agrawal R, Shirley DA, Patrie JT, Workman LJ, Schuyler AJ, Lawrence MG, Teague WG, Woodfolk JA, TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status., 2017; The Journal of allergy and clinical immunology. () PMID: 28939412 |

Heymann PW, Nguyen HT, Steinke JW, Turner RB, Woodfolk JA, Platts-Mills TAE, Martin L, He H, Biagini Myers J, Lindsey M, Sivaprasad U, Medvedovic M, Mahi N, Carper H, Murphy DD, Patrie J, Khurana Hershey GK, Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence., 2017; PloS one. 12(5) e0178096 PMID: 28552993 | PMCID: PMC5446117

Platts-Mills TAE, Woodfolk JA, Mite Avoidance as a Logical Treatment for Severe Asthma in Childhood. Why Not?, 2017; American journal of respiratory and critical care medicine. 196(2) 119-121 PMID: 28707970 |

Muehling LM, Lawrence MG, Woodfolk JA, Pathogenic CD4(+) T cells in patients with asthma., 2017; The Journal of allergy and clinical immunology. () PMID: 28442213 |

Turner RB, Woodfolk JA, Borish L, Steinke JW, Patrie JT, Muehling LM, Lahtinen S, Lehtinen MJ, Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection - a randomised controlled trial., 2017; Beneficial microbes. 8(2) 207-215 PMID: 28343401 |

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA, Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy., 2016; Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 46(11) 1389-1397 PMID: 27748974 |

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA, Developments in the field of allergy mechanisms in 2015 through the eyes of Clinical & Experimental Allergy., 2016; Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 46(10) 1248-57 PMID: 27682977 |

Platts-Mills TA, Heymann PW, Commins SP, Woodfolk JA, The discovery of IgE 50 years later., 2016; Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 116(3) 179-82 PMID: 26945493 |

Platts-Mills TAE, Schuyler AJ, Erwin EA, Commins SP, Woodfolk JA, IgE in the diagnosis and treatment of allergic disease., 2016; The Journal of allergy and clinical immunology. 137(6) 1662-1670 PMID: 27264001 | PMCID: PMC5406226

Woodfolk JA, Benign TH2 immunity in children: A?fresh perspective on control of the allergic response., 2016; The Journal of allergy and clinical immunology. 137(2) 388-9 PMID: 26853130 |

Muehling LM, Mai DT, Kwok WW, Heymann PW, Pom?s A, Woodfolk JA, Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans., 2016; Journal of immunology (Baltimore, Md. : 1950). 197(8) 3214-3224 PMID: 27591323 | PMCID: PMC5101128

Lawrence MG, Woodfolk JA, Schuyler AJ, Stillman LC, Chapman MD, Platts-Mills TA, Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease., 2016; The Journal of allergy and clinical immunology. 139(2) 422-428.e4 PMID: 27496596 | PMCID: PMC5405770

Woodfolk JA, Glesner J, Wright PW, Kepley CL, Li M, Himly M, Muehling LM, Gustchina A, Wlodawer A, Chapman MD, Pom?s A, Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2., 2015; The Journal of biological chemistry. 291(5) 2288-301 PMID: 26644466 | PMCID: PMC4732212

Woodfolk JA, Commins SP, Schuyler AJ, Erwin EA, Platts-Mills TA, Allergens, sources, particles, and molecules: Why do we make IgE responses?, 2015; Allergology international : official journal of the Japanese Society of Allergology. 64(4) 295-303 PMID: 26433525 |

Wisniewski JA, Commins SP, Agrawal R, Hulse KE, Yu MD, Cronin J, Heymann PW, Pomes A, Platts-Mills TA, Workman L, Woodfolk JA, Analysis of cytokine production by peanut-reactive T cells identifies residual Th2 effectors in highly allergic children who received peanut oral immunotherapy., 2015; Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 45(7) 1201-13 PMID: 25823600 | PMCID: PMC4472497

Erwin EA, Woodfolk JA, James HR, Satinover SM, Platts-Mills TA, Changes in cat specific IgE and IgG antibodies with decreased cat exposure., 2014; Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 112(6) 545-550.e1 PMID: 24726651 |

Allakhverdi Z, Comeau MR, Armant M, Agrawal R, Woodfolk JA, Sehmi R, Howie KJ, Gauvreau GM, Delespesse G, Mast Cell-Activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34(+) Progenitor Cells., 2014; Frontiers in immunology. 4() 461 PMID: 24381572 | PMCID: PMC3865761

Agrawal R, Wisniewski J, Yu MD, Kennedy JL, Platts-Mills T, Heymann PW, Woodfolk JA, Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics., 2014; Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 44(10) 1266-73 PMID: 25113532 | PMCID: PMC4191843

Agrawal R, Woodfolk JA, Skin barrier defects in atopic dermatitis., 2014; Current allergy and asthma reports. 14(5) 433 PMID: 24633617 | PMCID: PMC4034059

Agrawal R, Hulse K, Woodfolk JA, Targeting antibody receptors as an approach towards immunotherapy., 2014; Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen. 97() 153-6 PMID: 24912330 |

Romeo MJ, Agrawal R, Pom?s A, Woodfolk JA, Reply: To PMID 24084078., 2014; The Journal of allergy and clinical immunology. 134(3) 762-3 PMID: 25042745 | PMCID: PMC4547453

Romeo MJ, Agrawal R, Pom?s A, Woodfolk JA, A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease., 2013; The Journal of allergy and clinical immunology. 133(4) 952-60 PMID: 24084078 | PMCID: PMC3969406

Wisniewski JA, Agrawal R, Minnicozzi S, Xin W, Patrie J, Heymann PW, Workman L, Platts-Mills TA, Song TW, Moloney M, Woodfolk JA, Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis., 2013; Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 43(10) 1160-70 PMID: 24074334 | PMCID: PMC3801418

Platts-Mills TA, Woodfolk JA, Allergens and their role in the allergic immune response., 2011; Immunological reviews. 242(1) 51-68 PMID: 21682738 |

Hulse KE, Reefer AJ, Engelhard VH, Patrie JT, Ziegler SF, Chapman MD, Woodfolk JA, Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor., 2010; The Journal of allergy and clinical immunology. 125(1) 247-56.e1-8 PMID: 20109752 | PMCID: PMC2814452

Reefer AJ, Hulse KE, Lannigan JA, Solga MD, Wright PW, Kelly LA, Patrie J, Chapman MD, Woodfolk JA, Flow cytometry imaging identifies rare T(H)2 cells expressing thymic stromal lymphopoietin receptor in a "proallergic" milieu., 2010; The Journal of allergy and clinical immunology. 126(5) 1049-58, 1058.e1-10 PMID: 20888036 | PMCID: PMC3034251