Primary AppointmentMedicine- Asthma, Allergy and Immunology
Contact InformationTelephone: 434-924-1293 / 434-982-3958
Cellular and molecular mechanisms of allergic disease in humans.
Research in my lab focuses on improving our understanding of how the human immune system responds to environmental triggers of allergic disease. The prevalence of allergic diseases, including asthma, has risen dramatically in the last few decades. Exposure to rhinovirus, the major cause of common cold, is an important risk factor for acute asthma episodes. The primary objective of my work is to gain new insight into cellular mechanisms that promote pathogenic and protective responses to allergens and rhinovirus in humans. Current projects include: (1) Mechanisms of cross-protective adaptive immunity to human rhinovirus in an experimental human infection model; (2) Mechanisms of T-cell dysregulation in rhinovirus-induced asthma; and (3) The role of the TSLP pathway in allergic inflammation. Ongoing work uses novel tools and state-of-the-art technologies to provide a systems biology perspective of immune activation in humans. Our approach involves a high degree of collaboration with clinical specialists in adult and pediatric allergy/respiratory medicine, as well as with basic scientists in the fields of virology, biochemistry, genetics, transcriptomics, and single-cell analytics.