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Bochkis, Irina

Irina Bochkis

Primary Appointment


Contact Information

PO Box 800735
Charlottesville, VA 22908
Telephone: 434-982-6752
Fax: 434-982-3878

Research Interests

Epigenetic and genetic mechanisms underlying metabolic disease

Research Description

Our laboratory is interested in investigating how cellular processes govern proper metabolic function and how abnormal physiology leads to metabolic disease. In particular, we aim to understand genetic and epigenetic mechanisms regulating metabolism. We are focusing on genome-wide chromatin changes underlying physiological dysfunction, which include chromatin accessibility, nuclear localization & dynamics, and genome organization. Our laboratory utilizes functional genomics, chromatin biology, physiology, and transcriptional regulation in a comprehensive approach to decipher molecular mechanisms in mammalian models of human metabolic disease.

Selected Publications

Price AJ., Manjegowda MC., Kain J, Anandh S, Bochkis IM., Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver, ; Aging Cell. (2019) |

Whitton Holly , Singh Larry , Patrick MarissaA, Price AndrewJ, Osorio Fernando, Lopez-Otin Carols, Bochkis Irina M, Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver., ; Aging Cell . (0) |

Whitton H, Singh LN, Patrick MA, Price AJ, Osorio FG, L?pez-Ot?n C, Bochkis IM, Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver., 2018; Aging cell. () PMID: 29484800 |

Bochkis IM, Przybylski D, Chen J, Regev A, Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver., 2014; Cell reports. 9(3) 996-1006 PMID: 25437555 | PMCID: PMC4250828

Bochkis IM, Shin S, Kaestner KH, Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity., 2013; Molecular metabolism. 2(4) 447-56 PMID: 24327960 | PMCID: PMC3855091

Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, Barton MC, Kaestner KH, Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2., 2012; PLoS genetics. 8(6) e1002770 PMID: 22737085 | PMCID: PMC3380847

Bochkis IM, Schug J, Rubins NE, Chopra AR, O'Malley BW, Kaestner KH, Foxa2-dependent hepatic gene regulatory networks depend on physiological state., 2009; Physiological genomics. 38(2) 186-95 PMID: 19417011 | PMCID: PMC2712224

Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH, Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress., 2008; Nature medicine. 14(8) 828-36 PMID: 18660816 | PMCID: PMC4095974

Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH, Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3., 2007; Developmental biology. 306(2) 636-45 PMID: 17488644 | PMCID: PMC1952241

Phuc Le P, Friedman JR, Schug J, Brestelli JE, Parker JB, Bochkis IM, Kaestner KH, Glucocorticoid receptor-dependent gene regulatory networks., 2005; PLoS genetics. 1(2) e16 PMID: 16110340 | PMCID: PMC1186734