Epigenetic and genetic mechanisms underlying metabolic disease
Our laboratory is interested in investigating how cellular processes govern proper metabolic function and how abnormal physiology leads to metabolic disease. In particular, we aim to understand genetic and epigenetic mechanisms regulating metabolism. We are focusing on genome-wide chromatin changes underlying physiological dysfunction, which include chromatin accessibility, nuclear localization & dynamics, and genome organization. Our laboratory utilizes functional genomics, chromatin biology, physiology, and transcriptional regulation in a comprehensive approach to decipher molecular mechanisms in mammalian models of human metabolic disease.