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Agaisse, Herve

Herve Agaisse

Primary Appointment

Microbiology, Immunology, and Cancer Biology

Contact Information

Pinn Hall, 7th floor, Room 7221
Charlottesville, VA 22908
Fax: 434.982.1071
Email: hfa5y@virginia.edu
Website: https://mic.med.virginia.edu/agaisse/

Research Interests

Genetic approaches, cellular and molecular biology of intracellular pathogen infection

Research Description

The Agaisse Lab is associated with the Department of Microbiology, Immunology, and Cancer Biology (MIC). Our laboratory studies the bacterial pathogen Shigella flexneri, which causes approximately 270 million cases of bacillary dysentery (blood in stool) worldwide every year, resulting in more than 200,000 deaths. Our objective is to understand the molecular and cellular mechanisms supporting the disease in order to rationally design therapeutic interventions. We utilize a multi-disciplinary approach integrating molecular and cellular microbiology, bacterial and host cell genomics, bioinformatics and unique animal models of pathogenesis.

Selected Publications

K?seo?lu VK, Agaisse H, Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility., 2019; mBio. 10(4) PMID: 31455648 | PMCID: PMC6712393

Michard C, Yum LK, Agaisse H, WIPF2 promotes Shigella flexneri actin-based motility and cell-to-cell spread., 2019; Cellular microbiology. () e13098 PMID: 31414511 |

Yum LK, Byndloss MX, Feldman SH, Agaisse H, Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery., 2019; Nature communications. 10(1) 1826 PMID: 31015451 | PMCID: PMC6478941

K?seo?lu VK, Hall CP, Rodr?guez-L?pez EM, Agaisse H, The Autotransporter IcsA Promotes Shigella flexneri Biofilm Formation in the Presence of Bile Salts., 2019; Infection and immunity. 87(7) PMID: 30988059 | PMCID: PMC6589070

Q S Medeiros PH, Ledwaba SE, Bolick DT, Giallourou N, Yum LK, Costa DVS, Ori? RB, Barry EM, Swann JR, Lima A?M, Agaisse H, Guerrant RL, A murine model of diarrhea, growth impairment and metabolic disturbances with Shigella flexneri infection and the role of zinc deficiency., 2019; Gut microbes. 10(5) 615-630 PMID: 30712505 |

Anderson CJ, Satkovich J, K?seo?lu VK, Agaisse H, Kendall MM, The Ethanolamine Permease EutH Promotes Vacuole Adaptation of Salmonella enterica and Listeria monocytogenes during Macrophage Infection., 2018; Infection and immunity. 86(5) PMID: 29531136 | PMCID: PMC5913834

Weddle E, Agaisse H, Principles of intracellular bacterial pathogen spread from cell to cell., 2018; PLoS pathogens. 14(12) e1007380 PMID: 30543716 | PMCID: PMC6292572

Weddle E, Agaisse H, Spatial, Temporal, and Functional Assessment of LC3-Dependent Autophagy in Shigella flexneri Dissemination., 2018; Infection and immunity. 86(8) PMID: 29844234 | PMCID: PMC6056868

Rossi RM, Yum L, Agaisse H, Payne SM, Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence., 2017; mBio. 8(4) PMID: 28851846 | PMCID: PMC5574711

Alvarez DE, Agaisse H, The Metalloprotease Mpl Supports Listeria monocytogenes Dissemination through Resolution of Membrane Protrusions into Vacuoles., 2016; Infection and immunity. 84(6) 1806-14 PMID: 27068088 |

Agaisse H, Molecular and Cellular Mechanisms of Shigella flexneri Dissemination., 2016; Frontiers in cellular and infection microbiology. 6() 29 PMID: 27014639 | PMCID: PMC4786538

Kuehl CJ, Dragoi AM, Talman A, Agaisse H, Bacterial spread from cell to cell: beyond actin-based motility., 2015; Trends in microbiology. 23(9) 558-66 PMID: 26021574 | PMCID: PMC4560970

Agaisse H, Shigella flexneri serotype 3a: the rise of a superbug., 2015; The Lancet. Infectious diseases. 15(8) 867-8 PMID: 25936610 |

Dragoi AM, Agaisse H, The Class II Phosphatidylinositol 3-Phosphate Kinase PIK3C2A Promotes Shigella flexneri Dissemination through Formation of Vacuole-Like Protrusions., 2015; Infection and immunity. 83(4) 1695-704 PMID: 25667265 |

Borinskaya S, Velle KB, Campellone KG, Talman A, Alvarez D, Agaisse H, Wu YI, Loew LM, Mayer BJ, Integration of linear and dendritic actin nucleation in Nck-induced actin comets., 2015; Molecular biology of the cell. 27(2) 247-59 PMID: 26609071 | PMCID: PMC4713129

Dragoi AM, Swiss R, Gao B, Agaisse H, Novel strategies to enforce an epithelial phenotype in mesenchymal cells., 2014; Cancer research. 74(14) 3659-72 PMID: 24845104 | PMCID: PMC4102654

Kuehl CJ, Dragoi AM, Agaisse H, The Shigella flexneri type 3 secretion system is required for tyrosine kinase-dependent protrusion resolution, and vacuole escape during bacterial dissemination., 2014; PloS one. 9(11) e112738 PMID: 25405985 | PMCID: PMC4236203

Dragoi AM, Agaisse H, The serine/threonine kinase STK11 promotes Shigella flexneri dissemination through establishment of cell-cell contacts competent for tyrosine kinase signaling., 2014; Infection and immunity. 82(11) 4447-57 PMID: 25114112 | PMCID: PMC4249316

McDonough JA, Newton HJ, Klum S, Swiss R, Agaisse H, Roy CR, Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening., 2013; mBio. 4(1) e00606-12 PMID: 23362322 | PMCID: PMC3560531

Talman AM, Chong R, Chia J, Svitkina T, Agaisse H, Actin network disassembly powers dissemination of Listeria monocytogenes., 2013; Journal of cell science. 127(0) 240-9 PMID: 24155331 | PMCID: PMC3874788

Alvarez DE, Agaisse H, The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility., 2013; The Journal of cell biology. 202(7) 1075-90 PMID: 24062339 | PMCID: PMC3787377

Dragoi AM, Talman AM, Agaisse H, Bruton's tyrosine kinase regulates Shigella flexneri dissemination in HT-29 intestinal cells., 2012; Infection and immunity. 81(2) 598-607 PMID: 23230296 | PMCID: PMC3553807

Alvarez DE, Agaisse H, Casein kinase 2 regulates vaccinia virus actin tail formation., 2012; Virology. 423(2) 143-51 PMID: 22209233 |

Chong R, Squires R, Swiss R, Agaisse H, RNAi screen reveals host cell kinases specifically involved in Listeria monocytogenes spread from cell to cell., 2011; PloS one. 6(8) e23399 PMID: 21853127 | PMCID: PMC3154492

Chong R, Swiss R, Briones G, Stone KL, Gulcicek EE, Agaisse H, Regulatory mimicry in Listeria monocytogenes actin-based motility., 2009; Cell host & microbe. 6(3) 268-78 PMID: 19748468 | PMCID: PMC2752869

Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E, RNA interference screen for human genes associated with West Nile virus infection., 2008; Nature. 455(7210) 242-5 PMID: 18690214 | PMCID: PMC3136529

Derr? I, Pypaert M, Dautry-Varsat A, Agaisse H, RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection., 2007; PLoS pathogens. 3(10) 1446-58 PMID: 17967059 | PMCID: PMC2042019

Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE, Genome-wide RNAi screen for host factors required for intracellular bacterial infection., 2005; Science (New York, N.Y.). 309(5738) 1248-51 PMID: 16020693 |