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Rich, George

George Rich

Primary Appointment

Anesthesiology

Contact Information

Telephone: 434-924-2283
Email: gfr2f@virginia.edu

Research Interests

Research Description

Our research involves the role of endogenous nitric oxide/guanylate cyclase and other endothelial pathways in the control of vascular resistance. We are also interested in the effect of inhaled nitric oxide on pulmonary vascular resistance and its use in the treatment of pulmonary hypertension. Experiments are designed to model human diseases and to be clinically relevant. We perform acute and longterm experiments of induced pulmonary hypertension, utilizing a chronic hypoxia rat model. Other experiments include evaluation of inflammatory responses and the effects of inhibiting inducible endothelial enzymes, which may be partially responsible for sepsis-induced hypotension. Isolated lung and kidney models are used to study functional changes in vascular tone, associated with alterations of various endogenous endothelial pathways. We also evaluate protein and enzyme levels using western blots, light microscopy, and radioimmunoassays.

Selected Publications

de Klaver MJ, Weingart GS, Obrig TG, Rich GF, Local anesthetic-induced protection against lipopolysaccharide-induced injury in endothelial cells: the role of mitochondrial adenosine triphosphate-sensitive potassium channels., 2006; Anesthesia and analgesia. 102(4) 1108-13 PMID: 16551907 |

Fischer LG, Horstman DJ, Hahnenkamp K, Kechner NE, Rich GF, Selective iNOS inhibition attenuates acetylcholine- and bradykinin-induced vasoconstriction in lipopolysaccharide-exposed rat lungs., 1999; Anesthesiology. 91(6) 1724-32 PMID: 10598616 |

Frank DU, Horstman DJ, Morris GN, Johns RA, Rich GF, Regulation of the endogenous NO pathway by prolonged inhaled NO in rats., 1998; Journal of applied physiology (Bethesda, Md. : 1985). 85(3) 1070-8 PMID: 9729585 |

Frank DU, Lowson SM, Roos CM, Rich GF, Endotoxin alters hypoxic pulmonary vasoconstriction in isolated rat lungs., 1996; Journal of applied physiology (Bethesda, Md. : 1985). 81(3) 1316-22 PMID: 8889769 |