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Epstein, Frederick

Frederick Epstein

Primary Appointment

Biomedical Engineering

Contact Information

Telephone: 8049820211
Email: fhe6b@virginia.edu
Website: http://bme.virginia.edu/people/epstein.html

Research Interests

Cardiovascular Magnetic Resonance Imaging; Coronary Heart Disease; Myocardial Function; Myocardial Perfusion

Research Description

The general goal of my lab is to develop MRI techniques for assessing the structure, function, and perfusion of the cardiovascular system, particularly in the setting of heart disease. Recent projects have included developing MRI methods for imaging myocardial perfusion and developing displacement-encoded MRI for high-resolution measurements of intramyocardial motion. We have access to state-of-the-art whole body 3T scanners for human imaging studies and to a high-field 7T MRI scanner for imaging small animals, particularly mice. Through collaborations with cardiologists and molecular biologists, our novel MRI methods are applied to studies involving both clinical cardiology and basic cardiovascular science.Current Projects: Imaging myocardial mechanics with Cine DENSE (Displacement Encoding with Stimulated Echoes) MRI, including pulse sequence development and improving image analysis methods.

MRI in mouse models of cardiovascular disease.? Some projects include 3D Cine DENSE in mice, MRI of macrophage infiltration in myocardial infarction, using arterial spin labeling and first-pass MRI to quantify myocardial perfusion, T2-weighted imaging of myocardial edema, and 3D phase contrast MRI of aortic blood flow and wall shear stress.?

MRI of pancreatic beta cells using manganese and other targeted contrast agents as well as quantitation through MR relaxometry and multi-compartment models. Current Projects: Imaging myocardial mechanics with Cine DENSE (Displacement Encoding with Stimulated Echoes)MRI, including pulse sequence development and improving image analysis methods. MRI in mouse models of cardiovascular disease. Some projects include 3D Cine DENSE in mice, MRI of macrophage infiltration in myocardial infarction, using arterial spin labeling and first-pass MRI to quantify myocardial perfusion, T2-weighted imaging of myocardial edema, and 3D phase contrast MRI of aortic blood flow and wall shear stress. MRI of pancreatic beta cells using manganese and other targeted contrast agents as well as quantitation through MR relaxometry and multi-compartment models. UNLEASH: Undergraduates seeking work in this lab need to have coursework/experience in programming, linear algebra, and signal analysis.

Selected Publications

Ramachandran R, Chen X, Kramer CM, Epstein FH, Bilchick KC, Singular Value Decomposition Applied to Cardiac Strain from MR Imaging for Selection of Optimal Cardiac Resynchronization Therapy Candidates., 2015; Radiology. 275(2) 413-20 PMID: 25581423 | PMCID: PMC4456179

Nayak KS, Nielsen JF, Bernstein MA, Markl M, D Gatehouse P, M Botnar R, Saloner D, Lorenz C, Wen H, S Hu B, Epstein FH, N Oshinski J, Raman SV, Cardiovascular magnetic resonance phase contrast imaging., 2015; Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 17(1) 71 PMID: 26254979 |

Naresh NK, Chen X, Roy RJ, Antkowiak PF, Annex BH, Epstein FH, Accelerated dual-contrast first-pass perfusion MRI of the mouse heart: Development and application to diet-induced obese mice., 2014; Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. () PMID: 24760707 |

Rinkevich-Shop S, Landa-Rouben N, Epstein FH, Holbova R, Feinberg MS, Goitein O, Kushnir T, Konen E, Leor J, Injectable collagen implant improves survival, cardiac remodeling, and function in the early period after myocarditis in rats., 2014; Journal of cardiovascular pharmacology and therapeutics. 19(5) 470-80 PMID: 24572032 |

Jiji RS, Pollak AW, Epstein FH, Antkowiak PF, Meyer CH, Weltman AL, Lopez D, Dimaria JM, Hunter JR, Christopher JM, Kramer CM, Reproducibility of rest and exercise stress contrast-enhanced calf perfusion magnetic resonance imaging in peripheral arterial disease., 2013; Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 15() 14 PMID: 23343398 | PMCID: PMC3562222

Antkowiak PF, Stevens BK, Nunemaker CS, McDuffie M, Epstein FH, Manganese-enhanced magnetic resonance imaging detects declining pancreatic ?-cell mass in a cyclophosphamide-accelerated mouse model of type 1 diabetes., 2012; Diabetes. 62(1) 44-8 PMID: 22933107 | PMCID: PMC3526033

Tarroni G, Corsi C, Antkowiak PF, Veronesi F, Kramer CM, Epstein FH, Walter J, Lamberti C, Lang RM, Mor-Avi V, Patel AR, Myocardial perfusion: near-automated evaluation from contrast-enhanced MR images obtained at rest and during vasodilator stress., 2012; Radiology. 265(2) 576-83 PMID: 22893711 | PMCID: PMC3480816

Naresh NK, Xu Y, Klibanov AL, Vandsburger MH, Meyer CH, Leor J, Kramer CM, French BA, Epstein FH, Monocyte and/or macrophage infiltration of heart after myocardial infarction: MR imaging by using T1-shortening liposomes., 2012; Radiology. 264(2) 428-35 PMID: 22723500 | PMCID: PMC3401349

Pollak AW, Meyer CH, Epstein FH, Jiji RS, Hunter JR, Dimaria JM, Christopher JM, Kramer CM, Arterial spin labeling MR imaging reproducibly measures peak-exercise calf muscle perfusion: a study in patients with peripheral arterial disease and healthy volunteers., 2012; JACC. Cardiovascular imaging. 5(12) 1224-30 PMID: 23236972 | PMCID: PMC3531823

Salerno M, Janardhanan R, Jiji RS, Brooks J, Adenaw N, Mehta B, Yang Y, Antkowiak P, Kramer CM, Epstein FH, Comparison of methods for determining the partition coefficient of gadolinium in the myocardium using T(1) mapping., 2012; Journal of magnetic resonance imaging : JMRI. () PMID: 23197434 | PMCID: PMC3899916

Konkalmatt PR, Wang F, Piras BA, Xu Y, O'Connor DM, Beyers RJ, Epstein FH, Annex BH, Hossack JA, French BA, Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling., 2012; The journal of gene medicine. 14(9) 609-20 PMID: 23065925 | PMCID: PMC3729029

Epstein FH, Meyer CH, Myocardial perfusion using arterial spin labeling CMR: promise and challenges., 2011; JACC. Cardiovascular imaging. 4(12) 1262-4 PMID: 22172782 | PMCID: PMC3254141

Zhong X, Spottiswoode BS, Meyer CH, Kramer CM, Epstein FH, Imaging three-dimensional myocardial mechanics using navigator-gated volumetric spiral cine DENSE MRI., 2010; Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 64(4) 1089-97 PMID: 20574967 | PMCID: PMC2946451