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Marie, Chelsea

Chelsea Marie

Primary Appointment

Medicine- Infectious Diseases and International Health

Contact Information

UVA Division of Infectious Diseases
Charlottesville, VA 22908
Telephone: 434.243.3402

Research Interests

Human intestinal parasitology

Research Description

I am interested in the mucosal immune response to enteric pathogens. My current research includes understanding the cellular and immune mechanisms that underly environmental enteropathy in children in Bangladesh and patients with recurrent Clostridium difficile infection at UVa. My experimental research explores host factors identified in clinical cohorts as potential targets for host-directed therapeutics.

Selected Publications

Cowardin CA, Kuehne SA, Buonomo EL, Marie CS, Minton NP, Petri WA, Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile., 2015; mBio. 6(1) PMID: 25626905 | PMCID: PMC4324312

Marie C, Verkerke HP, Theodorescu D, Petri WA, A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica., 2015; Scientific reports. 5() 13613 PMID: 26346926 | PMCID: PMC4561901

Marie C, Petri WA, Regulation of virulence of Entamoeba histolytica., 2014; Annual review of microbiology. 68() 493-520 PMID: 25002094 |

Marie C, Petri WA, Amoebic dysentery., 2013; Clinical evidence. 2013() PMID: 23991750 | PMCID: PMC3758071

Verkerke HP, Petri WA, Marie CS, The dynamic interdependence of amebiasis, innate immunity, and undernutrition., 2012; Seminars in immunopathology. 34(6) 771-85 PMID: 23114864 | PMCID: PMC3510265

Marie CS, Verkerke HP, Paul SN, Mackey AJ, Petri WA, Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism., 2012; Infection and immunity. 80(5) 1934-43 PMID: 22331430 | PMCID: PMC3347425

Duggal P, Guo X, Haque R, Peterson KM, Ricklefs S, Mondal D, Alam F, Noor Z, Verkerke HP, Marie C, Leduc CA, Chua SC, Myers MG, Leibel RL, Houpt E, Gilchrist CA, Sher A, Porcella SF, Petri WA, A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children., 2011; The Journal of clinical investigation. 121(3) 1191-8 PMID: 21393862 | PMCID: PMC3049405

Marie C, White TC, Genetic Basis of Antifungal Drug Resistance., 2010; Current fungal infection reports. 3(3) 163-169 PMID: 20161440 | PMCID: PMC2790137

Marie C, Leyde S, White TC, Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae., 2008; Fungal genetics and biology : FG & B. 45(10) 1430-8 PMID: 18675371 | PMCID: PMC2580778