Primary AppointmentPublic Health Sciences
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
My laboratory's research focus involves the application of modern genomics and bioinformatics to unravel complex human diseases. By integrating large-scale human genetic association data with multi-omic profiling and clinically-relevant models, our work seeks to better understand causal disease mechanisms. We are dissecting the role of genetic and drug perturbations on vascular wall processes during atherosclerosis progression. We are also studying gene-gene and gene-environment interactions at the molecular level to further inform translational targeting of multiple risk loci.