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Venton, B.

B. Venton

Primary Appointment


Contact Information

PO Box 400319
Charlottesville, VIRGINIA 22904
Telephone: 4342432142

Research Interests

Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents

Research Description

Analytical Neurochemistry I am interested in the development and characterization of analytical techniques to measure neurochemical changes. Measurements in the brain are challenging because zeptomole quantities of neuroactive molecules must be detected in a chemically-complex sample while disturbing the tissue as little as possible. In addition, fast time resolution measurements are needed to track the fast dynamics of neurotransmitter release and uptake. The development of new analytical tools will enable a better understanding of the central nervous system which will, in turn, facilitate the development of new treatments for neurological disorders. Electrochemical Detection of Adenosine The goal of this project is to develop an electrochemical detection method for real-time monitoring of adenosine concentrations. Adenosine is a neuromodulator in the brain that has a variety of actions including regulation of cerebral blood flow, modulation of neurotransmission, and protection against neuronal injury during stroke. There is currently no reliable method for electrochemical detection of adenosine in vivo. Direct detection of adenosine using cyclic voltammetry at carbon-fiber microelectrodes is detected. The sensor is used to characterize extracellular adenosine release in the rat brain following electrical stimulation of neuronal activity and during ischemia, a model of stroke. Simultaneous monitoring of adenosine, oxygen and dopamine concentrations will allow studies of how adenosine modulates neurotransmission and cerebral blood flow. We are studying the modulation of adenosine during stroke. Measurements of Neurotransmitters in Drosophila Our lab also measures neurotransmitters in the Drosophila CNS. We use optogenetics as well as acetylcholine stimulations to elicit dopamine and serotonin release in the brain. We expect to study Parkinson models and test how dopamine differs through the life cycle of the fly.

Selected Publications

Ganesana M, Trikantzopoulos E, Maniar Y, Lee ST, Venton BJ, Development of a novel micro biosensor for in vivo monitoring of glutamate release in the brain., 2019; Biosensors & bioelectronics. 130() 103-109 PMID: 30731343 |

Shin M, Wang Y, Borgus JR, Venton BJ, Electrochemistry at the Synapse., 2019; Annual review of analytical chemistry (Palo Alto, Calif.). () PMID: 30707593 |

Puthongkham P, Yang C, Venton BJ, Carbon Nanohorn-Modified Carbon Fiber Microelectrodes for Dopamine Detection., 2019; Electroanalysis. 30(6) 1073-1081 PMID: 30613128 | PMCID: PMC6317378

Yang C, Hu K, Wang D, Zubi Y, Lee ST, Puthongkham P, Mirkin MV, Venton BJ, Cavity Carbon-Nanopipette Electrodes for Dopamine Detection., 2019; Analytical chemistry. () PMID: 30810304 |

Cao Q, Puthongkham P, Venton BJ, Review: New insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection., 2019; Analytical methods : advancing methods and applications. 11(3) 247-261 PMID: 30740148 | PMCID: PMC6366673

Wang Y, Venton BJ, Comparison of spontaneous and mechanically-stimulated adenosine release in mice., 2018; Neurochemistry international. 124() 46-50 PMID: 30579856 | PMCID: PMC6369016

Wang Y, Venton BJ, Caffeine Modulates Spontaneous Adenosine and Oxygen Changes during Ischemia and Reperfusion., 2018; ACS chemical neuroscience. () PMID: 30252436 |

Yang C, Cao Q, Puthongkham P, Lee ST, Ganesana M, Lavrik NV, Venton BJ, 3D-Printed Carbon Electrodes for Neurotransmitter Detection., 2018; Angewandte Chemie (International ed. in English). 57(43) 14255-14259 PMID: 30207021 | PMCID: PMC6334753

Ganesana M, Venton BJ, Early changes in transient adenosine during cerebral ischemia and reperfusion injury., 2018; PloS one. 13(5) e0196932 PMID: 29799858 |

Zestos AG, Venton BJ, Communication-Carbon Nanotube Fiber Microelectrodes for High Temporal Measurements of Dopamine., 2018; Journal of the Electrochemical Society. 165(12) G3071-G3073 PMID: 30197450 | PMCID: PMC6121781

Shin M, Copeland JM, Venton BJ, Drosophila as a Model System for Neurotransmitter Measurements., 2018; ACS chemical neuroscience. () PMID: 29411967 |

Shin M, Venton BJ, Electrochemical Measurements of Acetylcholine-Stimulated Dopamine Release in Adult Drosophila melanogaster Brains., 2018; Analytical chemistry. 90(17) 10318-10325 PMID: 30073836 | PMCID: PMC6135655

Haynes CL, Hummon A, Venton BJ, Virtual Issue Highlighting Selected Women Analytical Chemists., 2018; Analytical chemistry. 90(3) 1433 PMID: 29409170 |

Pyakurel P, Shin M, Venton BJ, Nicotinic acetylcholine receptor (nAChR) mediated dopamine release in larval Drosophila melanogaster., 2018; Neurochemistry international. 114() 33-41 PMID: 29305920 | PMCID: PMC5835409

Nguyen MD, Wang Y, Ganesana M, Venton BJ, Transient Adenosine Release Is Modulated by NMDA and GABAB Receptors., 2017; ACS chemical neuroscience. 8(2) 376-385 PMID: 28071892 | PMCID: PMC5558448

Lee ST, Venton BJ, Regional Variations of Spontaneous, Transient Adenosine Release in Brain Slices., 2017; ACS chemical neuroscience. 9(3) 505-513 PMID: 29135225 |

Yang C, Venton BJ, High Performance, Low Cost Carbon Nanotube Yarn based 3D Printed Electrodes Compatible with a Conventional Screen Printed Electrode System., 2017; IEEE International Symposium on Medical Measurements and Applications : proceedings. IEEE International Symposium on Medical Measurements and Applications. 2017() 100-105 PMID: 28890951 | PMCID: PMC5589149

Yang C, Wang Y, Jacobs CB, Ivanov IN, Venton BJ, O2 Plasma Etching and Antistatic Gun Surface Modifications for CNT Yarn Microelectrode Improve Sensitivity and Antifouling Properties., 2017; Analytical chemistry. 89(10) 5605-5611 PMID: 28423892 | PMCID: PMC5575992

Yang C, Trikantzopoulos E, Jacobs CB, Venton BJ, Evaluation of carbon nanotube fiber microelectrodes for neurotransmitter detection: Correlation of electrochemical performance and surface properties., 2017; Analytica chimica acta. 965() 1-8 PMID: 28366206 | PMCID: PMC5380235

Borman RP, Wang Y, Nguyen MD, Ganesana M, Lee ST, Venton BJ, Automated Algorithm for Detection of Transient Adenosine Release., 2017; ACS chemical neuroscience. 8(2) 386-393 PMID: 28196418 | PMCID: PMC5312768

Ganesana M, Lee ST, Wang Y, Venton BJ, Analytical Techniques in Neuroscience: Recent Advances in Imaging, Separation, and Electrochemical Methods., 2017; Analytical chemistry. 89(1) 314-341 PMID: 28105819 | PMCID: PMC5260807

Trikantzopoulos E, Yang C, Ganesana M, Wang Y, Venton BJ, Novel carbon-fiber microelectrode batch fabrication using a 3D-printed mold and polyimide resin., 2016; The Analyst. 141(18) 5256-5260 PMID: 27536741 | PMCID: PMC5019535

Yang C, Trikantzopoulos E, Nguyen MD, Jacobs CB, Wang Y, Mahjouri-Samani M, Ivanov IN, Venton BJ, Laser Treated Carbon Nanotube Yarn Microelectrodes for Rapid and Sensitive Detection of Dopamine in Vivo., 2016; ACS sensors. 1(5) 508-515 PMID: 27430021 | PMCID: PMC4944855

Pyakurel P, Privman Champaloux E, Venton BJ, Fast-Scan Cyclic Voltammetry (FSCV) Detection of Endogenous Octopamine in Drosophila melanogaster Ventral Nerve Cord., 2016; ACS chemical neuroscience. 7(8) 1112-9 PMID: 27326831 | PMCID: PMC4988909

Wang Y, Venton BJ, Correlation of transient adenosine release and oxygen changes in the caudate-putamen., 2016; Journal of neurochemistry. 140(1) 13-23 PMID: 27314215 | PMCID: PMC5164875

Nguyen MD, Ross AE, Ryals M, Lee ST, Venton BJ, Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism., 2016; Pharmacology research & perspectives. 3(6) e00189 PMID: 27022463 | PMCID: PMC4777247

Nguyen MD, Venton BJ, Fast-scan Cyclic Voltammetry for the Characterization of Rapid Adenosine Release., 2016; Computational and structural biotechnology journal. 13() 47-54 PMID: 26900429 | PMCID: PMC4720017

Denno ME, Privman E, Borman RP, Wolin DC, Venton BJ, Quantification of Histamine and Carcinine in Drosophila melanogaster Tissues., 2016; ACS chemical neuroscience. 7(3) 407-14 PMID: 26765065 | PMCID: PMC4798850

Yang C, Jacobs CB, Nguyen MD, Ganesana M, Zestos AG, Ivanov IN, Puretzky AA, Rouleau CM, Geohegan DB, Venton BJ, Carbon Nanotubes Grown on Metal Microelectrodes for the Detection of Dopamine., 2015; Analytical chemistry. 88(1) 645-52 PMID: 26639609 | PMCID: PMC4718531

Zestos AG, Yang C, Jacobs CB, Hensley D, Venton BJ, Carbon nanospikes grown on metal wires as microelectrode sensors for dopamine., 2015; The Analyst. 140(21) 7283-92 PMID: 26389138 | PMCID: PMC4618699

Yang C, Denno ME, Pyakurel P, Venton BJ, Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review., 2015; Analytica chimica acta. 887() 17-37 PMID: 26320782 | PMCID: PMC4557208

Privman E, Venton BJ, Comparison of dopamine kinetics in the larval Drosophila ventral nerve cord and protocerebrum with improved optogenetic stimulation., 2015; Journal of neurochemistry. 135(4) 695-704 PMID: 26296526 | PMCID: PMC4636934

Xiao N, Venton BJ, Characterization of dopamine releasable and reserve pools in Drosophila larvae using ATP/P2X2 -mediated stimulation., 2015; Journal of neurochemistry. 134(3) 445-54 PMID: 25951875 | PMCID: PMC4496298

Rees HR, Anderson SE, Privman E, Bau HH, Venton BJ, Carbon nanopipette electrodes for dopamine detection in Drosophila., 2015; Analytical chemistry. 87(7) 3849-55 PMID: 25711512 | PMCID: PMC4400659

Xiao N, Privman E, Venton BJ, Optogenetic control of serotonin and dopamine release in Drosophila larvae., 2014; ACS chemical neuroscience. 5(8) 666-73 PMID: 24849718 | PMCID: PMC4140588

Jacobs CB, Ivanov IN, Nguyen MD, Zestos AG, Venton BJ, High temporal resolution measurements of dopamine with carbon nanotube yarn microelectrodes., 2014; Analytical chemistry. 86(12) 5721-7 PMID: 24832571 | PMCID: PMC4063327

Ross AE, Nguyen MD, Privman E, Venton BJ, Mechanical stimulation evokes rapid increases in extracellular adenosine concentration in the prefrontal cortex., 2014; Journal of neurochemistry. 130(1) 50-60 PMID: 24606335 | PMCID: PMC4065624

Nguyen MD, Lee ST, Ross AE, Ryals M, Choudhry VI, Venton BJ, Characterization of spontaneous, transient adenosine release in the caudate-putamen and prefrontal cortex., 2014; PloS one. 9(1) e87165 PMID: 24494035 | PMCID: PMC3907895

Ross AE, Venton BJ, Adenosine transiently modulates stimulated dopamine release in the caudate-putamen via A1 receptors., 2014; Journal of neurochemistry. () PMID: 25219576 |

Zestos AG, Jacobs CB, Trikantzopoulos E, Ross AE, Venton BJ, Polyethylenimine carbon nanotube fiber electrodes for enhanced detection of neurotransmitters., 2014; Analytical chemistry. 86(17) 8568-75 PMID: 25117550 | PMCID: PMC4151793

Ross AE, Venton BJ, Sawhorse waveform voltammetry for selective detection of adenosine, ATP, and hydrogen peroxide., 2014; Analytical chemistry. 86(15) 7486-93 PMID: 25005825 |

Fang H, Pajski ML, Ross AE, Venton BJ, Quantitation of dopamine, serotonin and adenosine content in a tissue punch from a brain slice using capillary electrophoresis with fast-scan cyclic voltammetry detection., 2013; Analytical methods : advancing methods and applications. 5(11) 2704-2711 PMID: 23795210 | PMCID: PMC3686531

Vickrey TL, Xiao N, Venton BJ, Kinetics of the dopamine transporter in Drosophila larva., 2013; ACS chemical neuroscience. 4(5) 832-7 PMID: 23600464 | PMCID: PMC3656763

Pajski ML, Venton BJ, The mechanism of electrically stimulated adenosine release varies by brain region., 2012; Purinergic signalling. () PMID: 23192278 | PMCID: PMC3646118

Glanowska KM, Venton BJ, Moenter SM, Fast scan cyclic voltammetry as a novel method for detection of real-time gonadotropin-releasing hormone release in mouse brain slices., 2012; The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(42) 14664-9 PMID: 23077052 | PMCID: PMC3492948

Xiao N, Venton BJ, Rapid, sensitive detection of neurotransmitters at microelectrodes modified with self-assembled SWCNT forests., 2012; Analytical chemistry. 84(18) 7816-22 PMID: 22823497 | PMCID: PMC3445787

Ross AE, Venton BJ, Nafion-CNT coated carbon-fiber microelectrodes for enhanced detection of adenosine., 2012; The Analyst. 137(13) 3045-51 PMID: 22606688 | PMCID: PMC3392196

Vickrey TL, Venton BJ, Drosophila Dopamine2-like receptors function as autoreceptors., 2012; ACS chemical neuroscience. 2(12) 723-729 PMID: 22308204 | PMCID: PMC3269839

Jacobs CB, Vickrey TL, Venton BJ, Functional groups modulate the sensitivity and electron transfer kinetics of neurochemicals at carbon nanotube modified microelectrodes., 2011; The Analyst. 136(17) 3557-65 PMID: 21373669 | PMCID: PMC4169050

Fang H, Vickrey TL, Venton BJ, Analysis of biogenic amines in a single Drosophila larva brain by capillary electrophoresis with fast-scan cyclic voltammetry detection., 2011; Analytical chemistry. 83(6) 2258-64 PMID: 21322586 | PMCID: PMC3058613

Pajski ML, Venton BJ, Adenosine Release Evoked by Short Electrical Stimulations in Striatal Brain Slices is Primarily Activity Dependent., 2011; ACS chemical neuroscience. 1(12) 775-787 PMID: 21218131 | PMCID: PMC3016054

Kile BM, Guillot TS, Venton BJ, Wetsel WC, Augustine GJ, Wightman RM, Synapsins differentially control dopamine and serotonin release., 2010; The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(29) 9762-70 PMID: 20660258 | PMCID: PMC2923550

Cechova S, Elsobky AM, Venton BJ, A1 receptors self-regulate adenosine release in the striatum: evidence of autoreceptor characteristics., 2010; Neuroscience. 171(4) 1006-15 PMID: 20933584 | PMCID: PMC2991493

Xu Y, Venton BJ, Rapid determination of adenosine deaminase kinetics using fast-scan cyclic voltammetry., 2010; Physical chemistry chemical physics : PCCP. 12(34) 10027-32 PMID: 20577678 |

Borue X, Condron B, Venton BJ, Both synthesis and reuptake are critical for replenishing the releasable serotonin pool in Drosophila., 2010; Journal of neurochemistry. 113(1) 188-99 PMID: 20070864 | PMCID: PMC2860618

Jacobs CB, Peairs MJ, Venton BJ, Review: Carbon nanotube based electrochemical sensors for biomolecules., 2010; Analytica chimica acta. 662(2) 105-27 PMID: 20171310 |

Vickrey TL, Condron B, Venton BJ, Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry., 2009; Analytical chemistry. 81(22) 9306-13 PMID: 19842636 | PMCID: PMC2876717

Cooper SE, Venton BJ, Fast-scan cyclic voltammetry for the detection of tyramine and octopamine., 2009; Analytical and bioanalytical chemistry. 394(1) 329-36 PMID: 19189084 |

Borue X, Cooper S, Hirsh J, Condron B, Venton BJ, Quantitative evaluation of serotonin release and clearance in Drosophila., 2009; Journal of neuroscience methods. 179(2) 300-8 PMID: 19428541 | PMCID: PMC2691387

Huffman ML, Venton BJ, Carbon-fiber microelectrodes for in vivo applications., 2008; The Analyst. 134(1) 18-24 PMID: 19082168 | PMCID: PMC2684111

Strand AM, Venton BJ, Flame etching enhances the sensitivity of carbon-fiber microelectrodes., 2008; Analytical chemistry. 80(10) 3708-15 PMID: 18416534 |

Cechova S, Venton BJ, Transient adenosine efflux in the rat caudate-putamen., 2008; Journal of neurochemistry. 105(4) 1253-63 PMID: 18194431 |

Swamy BE, Venton BJ, Subsecond detection of physiological adenosine concentrations using fast-scan cyclic voltammetry., 2007; Analytical chemistry. 79(2) 744-50 PMID: 17222045 |

Swamy BE, Venton BJ, Carbon nanotube-modified microelectrodes for simultaneous detection of dopamine and serotonin in vivo., 2007; The Analyst. 132(9) 876-84 PMID: 17710262 |

Venton BJ, Wightman RM, Pharmacologically induced, subsecond dopamine transients in the caudate-putamen of the anesthetized rat., 2006; Synapse (New York, N.Y.). 61(1) 37-9 PMID: 17068772 |

Venton BJ, Robinson TE, Kennedy RT, Maren S, Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear., 2006; The European journal of neuroscience. 23(12) 3391-8 PMID: 16820029 |

Watson CJ, Venton BJ, Kennedy RT, In vivo measurements of neurotransmitters by microdialysis sampling., 2006; Analytical chemistry. 78(5) 1391-9 PMID: 16570388 |

Venton BJ, Seipel AT, Phillips PE, Wetsel WC, Gitler D, Greengard P, Augustine GJ, Wightman RM, Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool., 2006; The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(12) 3206-9 PMID: 16554471 |

Venton BJ, Robinson TE, Kennedy RT, Transient changes in nucleus accumbens amino acid concentrations correlate with individual responsivity to the predator fox odor 2,5-dihydro-2,4,5-trimethylthiazoline., 2005; Journal of neurochemistry. 96(1) 236-46 PMID: 16300631 |

Venton BJ, Zhang H, Garris PA, Phillips PE, Sulzer D, Wightman RM, Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing., 2003; Journal of neurochemistry. 87(5) 1284-95 PMID: 14622108 |

Robinson DL, Venton BJ, Heien ML, Wightman RM, Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo., 2003; Clinical chemistry. 49(10) 1763-73 PMID: 14500617 |

Garris PA, Budygin EA, Phillips PE, Venton BJ, Robinson DL, Bergstrom BP, Rebec GV, Wightman RM, A role for presynaptic mechanisms in the actions of nomifensine and haloperidol., 2003; Neuroscience. 118(3) 819-29 PMID: 12710989 |

Venton BJ, Michael DJ, Wightman RM, Correlation of local changes in extracellular oxygen and pH that accompany dopaminergic terminal activity in the rat caudate-putamen., 2003; Journal of neurochemistry. 84(2) 373-81 PMID: 12558999 |

Troyer KP, Heien ML, Venton BJ, Wightman RM, Neurochemistry and electroanalytical probes., 2002; Current opinion in chemical biology. 6(5) 696-703 PMID: 12413556 |

Venton BJ, Troyer KP, Wightman RM, Response times of carbon fiber microelectrodes to dynamic changes in catecholamine concentration., 2002; Analytical chemistry. 74(3) 539-46 PMID: 11838672 |