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Manichaikul, Ani

Ani Manichaikul

Primary Appointment

Public Health Sciences

Contact Information

Telephone: 2-1612
Email: am3xa@virginia.edu
Website: http://people.virginia.edu/~am3xa/

Research Interests

Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis

Research Description

My research lies in the areas of statistical genetics and genetic epidemiology with an emphasis on 1) analysis of genome-wide association studies in the multi-ethnic cohort studies, 2) gene-based analysis of rare variants, 3) quantitative trait mapping in experimental crosses, and 4) translational research efforts bridging mouse and human studies. I am actively involved in genome-wide association analysis of cardiovascular and pulmonary phenotypes performed through the Multi-Ethnic Study of Atherosclerosis (MESA). We are performing post-GWAS research, including gene-environment interaction studies, fine mapping studies, and candidate gene investigations with collaborators who are experts in animal models and in vitro studies of more focused genetic pathways. We are working actively on integrative 'omics combining genomic, transcriptomic, proteomic and other high-dimensional data sets from the NHLBI Trans-omics for Precision Medicine (TOPMed) project, the Genotype-Tissue Expression (GTEx) project, and others to identify causal genes and pathways influencing diseases of interest.

Selected Publications

Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Mill..., Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis., 2019; American journal of respiratory and critical care medicine. () PMID: 31710517 |

Liang J, Cade BE, He KY, Wang H, Lee J, Sofer T, Williams S, Li R, Chen H, Gottlieb DJ, Evans DS, Guo X, Gharib SA, Hale L, Hillman DR, Lutsey PL, Mukherjee S, Ochs-Balcom HM, Palmer LJ, Rhodes J, Purcell S, Patel SR, Saxena R, Stone KL, Tang W, T..., Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level., 2019; American journal of human genetics. 105(5) 1057-1068 PMID: 31668705 | PMCID: PMC6849112

Manichaikul A, Peres LC, Wang XQ, Barnard ME, Chyn D, Sheng X, Du Z, Tyrer J, Dennis J, Schwartz AG, Cote ML, Peters E, Moorman PG, Bondy M, Barnholtz-Sloan JS, Terry P, Alberg AJ, Bandera EV, Funkhouser E, Wu AH, Pearce CL, Pike M, Setiawan VW, H..., Identification of novel epithelial ovarian cancer loci in women of African ancestry., 2019; International journal of cancer. () PMID: 31469419 |

Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong..., Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations., 2019; Nature genetics. 51(3) 494-505 PMID: 30804561 | PMCID: PMC6546635

Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, Smith AV, Sun F, Terzikhan N, Markunas CA, Patchen BK, Schu M, Beydoun MA, Brusselle GG, Eiriksdottir G, Zhou X, Wood AC, Graff M, Harris TB, Ikram MA, Jacobs DR, Launer LJ, Lemaitre RN..., Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association., 2018; American journal of respiratory and critical care medicine. 199(5) 631-642 PMID: 30199657 | PMCID: PMC6396866

Natarajan P, Peloso GM, Zekavat SM, Montasser M, Ganna A, Chaffin M, Khera AV, Zhou W, Bloom JM, Engreitz JM, Ernst J, O'Connell JR, Ruotsalainen SE, Alver M, Manichaikul A, Johnson WC, Perry JA, Poterba T, Seed C, Surakka IL, Esko T, Ripatti S, S..., Deep-coverage whole genome sequences and blood lipids among 16,324 individuals., 2018; Nature communications. 9(1) 3391 PMID: 30140000 | PMCID: PMC6107638

Wyss AB, Sofer T, Lee MK, Terzikhan N, Nguyen JN, Lahousse L, Latourelle JC, Smith AV, Bartz TM, Feitosa MF, Gao W, Ahluwalia TS, Tang W, Oldmeadow C, Duan Q, de Jong K, Wojczynski MK, Wang XQ, Noordam R, Hartwig FP, Jackson VE, Wang T, Obeidat M,..., Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function., 2018; Nature communications. 9(1) 2976 PMID: 30061609 | PMCID: PMC6065313

Burkart KM, Sofer T, London SJ, Manichaikul A, Hartwig FP, Yan Q, Soler Artigas M, Avila L, Chen W, Davis Thomas S, Diaz AA, Hall IP, Horta BL, Kaplan RC, Laurie CC, Menezes AM, Morrison JV, Oelsner EC, Rastogi D, Rich SS, Soto-Quiros M, Stilp AM,..., A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos., 2018; American journal of respiratory and critical care medicine. 198(2) 208-219 PMID: 29394082 | PMCID: PMC6058984

Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV, Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR, Kanner RE, Kaufman JD, Kleerup E, Lin CL, Liu K, Lo Cascio CM, Martinez FJ, Ngu..., Human airway branch variation and chronic obstructive pulmonary disease., 2018; Proceedings of the National Academy of Sciences of the United States of America. 115(5) E974-E981 PMID: 29339516 | PMCID: PMC5798356

Manichaikul A, Nguyen JN, Genetic studies as a tool for identifying novel potential targets for treatment of?COPD., 2017; The European respiratory journal. 50(5) PMID: 29191956 | PMCID: PMC5871433